Jan 8, 2009

Oxidative stress in developmental origins of disease: teratogenesis, neurodevelopmental deficits, and cancer

Toxicological Sciences : an Official Journal of the Society of Toxicology
Peter G WellsAndrea W Wong

Abstract

In the developing embryo and fetus, endogenous or xenobiotic-enhanced formation of reactive oxygen species (ROS) like hydroxyl radicals may adversely alter development by oxidatively damaging cellular lipids, proteins and DNA, and/or by altering signal transduction. The postnatal consequences may include an array of birth defects (teratogenesis), postnatal functional deficits, and diseases. In animal models, the adverse developmental consequences of in utero exposure to agents like thalidomide, methamphetamine, phenytoin, benzo[a]pyrene, and ionizing radiation can be modulated by altering pathways that control the embryonic ROS balance, including enzymes that bioactivate endogenous substrates and xenobiotics to free radical intermediates, antioxidative enzymes that detoxify ROS, and enzymes that repair oxidative DNA damage. ROS-mediated signaling via Ras, nuclear factor kappa B and related transducers also may contribute to altered development. Embryopathies can be reduced by free radical spin trapping agents and antioxidants, and enhanced by glutathione depletion. Further modulatory approaches to evaluate such mechanisms in vivo and/or in embryo culture have included the use of knockout mice, transgenic knock-ins and mutant de...Continue Reading

  • References59
  • Citations158

References

Mentioned in this Paper

Embryo
Cranioschisis
Biochemical Pathway
Enzyme Inhibitor Drugs
Depression, Postpartum
Embryopathies
Enzymes, antithrombotic
Uterus
Antioxidants
Embryo AND Fetus

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Antisense Oligonucleotides: ND

This feed focuses on antisense oligonucleotide therapies such as Inotersen, Nusinursen, and Patisiran, in neurodegenerative diseases including amyotrophic lateral sclerosis.

Antisense Oligonucleotide - Therapies For ALS

This feed focuses on antisense oligonucleotide therapies such as Inotersen, Nusinursen, and Patisiran, in neurodegenerative diseases including amyotrophic lateral sclerosis.

Related Papers

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Andrea W WongPeter G Wells
Birth Defects Research. Part C, Embryo Today : Reviews
Peter G WellsStephanie L Ondovcik
© 2020 Meta ULC. All rights reserved