Oxidative stress in electrohypersensitivity self‑reporting patients: Results of a prospective in vivo investigation with comprehensive molecular analysis

International Journal of Molecular Medicine
Philippe IrigarayDominique Belpomme

Abstract

A total of 32 electrohypersensitivity (EHS) self‑reporting patients were serially included in the present prospective study for oxidative stress and antioxidative stress response assessment. All thiobarbituric acid‑reactive substances (TBARs) were measured in the plasma, particularly malondialdehyde (MDA) for lipid peroxidation; additional measurements included total thiol group molecules, reduced glutathione (GSH), oxidized glutathione (GSSG) for oxidative stress assessment and nitrotyrosine, a marker of peroxynitrite‑induced oxidative/nitrosative stress. In addition, the activity of Cu‑Zn superoxide dismutase (SOD1) was measured in red blood cells (RBCs) and glutathione reductase (GR) and glutathione peroxidase (GPx) in RBCs and plasma. Depending of the biomarker considered, 30‑50% of EHS self‑reporting patients presented statistically significantly increased TBARs, MDA, GSSG and NTT mean plasmatic level values in comparison with normal values obtained in healthy controls (P<0.0001). By contrast, there were no plasmatic level values above the upper normal limits for GSH, GSH/GSSG ratio, total glutathione (GluT) and GSH/GluT ratio, and values for these GSH‑associated biomarkers were statistically significantly decreased in 20‑...Continue Reading

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Citations

Mar 11, 2020·Electromagnetic Biology and Medicine·Fabien Deruelle
Mar 15, 2020·International Journal of Molecular Sciences·Dominique Belpomme, Philippe Irigaray
Oct 8, 2021·Reviews on Environmental Health·Dariusz Leszczynski
Jul 7, 2021·Reviews on Environmental Health·Dariusz Leszczynski

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Methods Mentioned

BETA
MDA
ELISA
dissection

Software Mentioned

XLSTAT
EMFIS

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