Oxidative stress in mononuclear cells plays a dominant role in their adhesion to mouse femoral artery after injury

Hypertension
Sumihiko HagitaMasayuki Yoshida

Abstract

Leukocyte recruitment plays a pivotal role during inflammation after vascular injury. The importance of oxidative stress in vascular injury and its modulation by angiotensin II receptor blockers (olmesartan) have been demonstrated. We examined the contribution of leukocyte-associated oxidative stress in acute-phase leukocyte recruitment and its modulation by olmesartan. Male mice were treated with olmesartan (5 mg/kg per day) or vehicle for 7 days before the transluminal wire injury of the femoral artery. Intravital microscopy of the artery revealed that the mechanical injury increased adherent leukocytes at both 24 hours and 7 days after the injury, which was significantly reduced by olmesartan treatment. Dihydroethidium-associated fluorescence intensity observed in vehicle-treated mice was significantly diminished under olmesartan treatment. Apocynin, a nicotinamide-adenine dinucleotide phosphate oxidase inhibitor, showed a similar inhibitory effect on the leukocyte adhesion. Adoptive transfer of mononuclear cells, harvested from mice after wire injury, but not from those without wire injury, exhibited adhesion to the recipient injured artery. Furthermore, olmesartan treatment of mononuclear cells, but not of injured vasculat...Continue Reading

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Citations

Jan 29, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Sumihiko HagitaMasayuki Yoshida
Oct 13, 2010·The Journal of Biological Chemistry·Shunsuke ItoMasayuki Yoshida
Sep 17, 2009·Journal of Atherosclerosis and Thrombosis·Maria KimouliDemetrios A Spandidos
Nov 13, 2009·Journal of Atherosclerosis and Thrombosis·Kotaro AiharaMasayuki Yoshida
Sep 26, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Jun InoMasayuki Yoshida
Feb 7, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xueyang FangTianfeng Chen
Jan 31, 2013·Journal of Leukocyte Biology·Shunsuke ItoMasayuki Yoshida
Feb 11, 2016·Journal of Atherosclerosis and Thrombosis·Shunsuke ItoMasayuki Yoshida

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