Oxidative stress in mouse plasma and lungs induced by cigarette smoke and lipopolysaccharide

Environmental Research
Samuel Santos ValençaLuís Cristóvão Porto

Abstract

Short-term exposure to cigarette smoke (CS) or lipopolysaccharide (LPS) leads to acute lung inflammation through oxidant-antioxidant imbalance. We studied the response in mice exposed to smoke or LPS during five consecutive days, as measured by superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities, as well as lipid peroxidation and nitric oxide levels in bronchoalveolar lavage fluid (BALF), lung homogenates, and plasma. Control mice were exposed to ambient air. Exposure to CS or LPS led to a similar influx of alveolar macrophages and neutrophils into the BALF; however, hydroxyproline levels were increased only in the CS group (p<0.001); SOD activity was increased in the BALF (p<0.001) and lung homogenates (p<0.05) of the CS group but was decreased in the BALF (p<0.05), lung homogenates (p<0.05) and plasma (p<0.01) of the LPS group. CAT activity was increased in the BALF (p<0.01), lung homogenates (p<0.001) and plasma (p<0.05) of the CS group but decreased in the BALF (p<0.001) and plasma (p<0.05) of the LPS group. GPx activity was reduced in the BALF (p<0.01) and plasma (p<0.01) of both the CS and LPS groups. Lipid peroxidation was increased in the BALF (p<0.001) and lung homogenates (p<0.001) ...Continue Reading

References

Jun 1, 1990·Atherosclerosis·E SchefflerH A Dresel
Oct 1, 1982·Analytical Biochemistry·L C GreenS R Tannenbaum
Aug 1, 1995·American Journal of Respiratory and Critical Care Medicine·S A KharitonovP J Barnes
Jan 1, 1994·American Journal of Respiratory and Critical Care Medicine·T KondoY Kawakami
Jan 1, 1996·Free Radical Biology & Medicine·T D OuryJ D Crapo
Nov 7, 1998·American Journal of Respiratory Cell and Molecular Biology·Y SuE R Block
Feb 5, 2000·American Journal of Respiratory Cell and Molecular Biology·R DhamiA Churg
Mar 4, 2000·The European Respiratory Journal·D S FaffeW A Zin
Jun 8, 2001·Journal of Hypertension·L RaijE A Jaimes
Sep 5, 2002·Clinical Chemistry and Laboratory Medicine : CCLM·Leyla YildizHülya Aksoy
Nov 26, 2002·Free Radical Biology & Medicine·Sharanya ReddyAlbert van der Vliet
Mar 26, 2003·Experimental Lung Research·Jeffrey C HoytPeter J Barnes
Mar 17, 2004·Proceedings of the National Academy of Sciences of the United States of America·Rafael Radi
Jul 30, 2004·Thorax·H van der VaartN H T ten Hacken
Nov 2, 2004·The European Respiratory Journal·T HarjuV L Kinnula
Jul 1, 2005·Treatments in Respiratory Medicine·Irfan Rahman
May 27, 2006·Current Pharmaceutical Biotechnology·W DomejB Haditsch
Jul 4, 2006·The European Respiratory Journal·I Rahman, I M Adcock
Aug 22, 2006·Proceedings of the American Thoracic Society·Rubin M TuderIrina Petrache
Sep 13, 2006·International Journal of Experimental Pathology·Samuel Santos ValencaLuís Cristóvão Porto
Nov 14, 2006·Biochemical and Biophysical Research Communications·Rajesh K ThimmulappaShyam Biswal
Apr 24, 2007·Respiratory Medicine·Ruzena TkacovaAngela Molcanyiova

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Citations

Sep 29, 2011·Journal of Molecular Histology·Ki Youn JungSang-Yoon Nam
Aug 2, 2011·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Karla Maria Pereira PiresRoberto Soares de Moura
Mar 26, 2013·PloS One·Mohamed Abdelmonem FahimMohamed Yousif Hasan
Sep 15, 2011·Clinical Chemistry and Laboratory Medicine : CCLM·Sibel DorukZehra Seyfikli
Mar 29, 2014·Critical Care : the Official Journal of the Critical Care Forum·Jan HirschJames A Frank
Jun 17, 2014·Respiratory Physiology & Neurobiology·Mariana Nascimento MachadoWalter Araújo Zin
Jun 12, 2014·Chinese Journal of Integrative Medicine·Lu-ping TangRong-rong He
Jun 17, 2014·Inhalation Toxicology·Masayuki ItohKazutetsu Aoshiba
Nov 30, 2011·Inhalation Toxicology·Eduardo Tavares Lima TrajanoSamuel Santos Valença
Aug 21, 2012·Free Radical Research·Way Kwok-Wai LauJudith Choi-Wo Mak
Mar 29, 2014·Experimental Lung Research·Keila Karine Duarte CamposWanderson Geraldo Lima
May 24, 2011·Pharmacological Reports : PR·Aleksandra PiechotaAnna Goraca
Mar 10, 2012·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Manar A Nader, Hany N Baraka
Dec 27, 2011·Free Radical Biology & Medicine·Erin N Potts-KantJohn W Hollingsworth
Dec 15, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Roberto Soares de MouraSamuel Santos Valenca
May 27, 2009·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Tapan M BhavsarCesar A Lau-Cam
Dec 17, 2008·Nitric Oxide : Biology and Chemistry·Samuel Santos ValençaLuís Cristóvão Porto
Sep 12, 2015·Toxicology Mechanisms and Methods·Naif O Al-HarbiSaleh Bahashwan
Jul 15, 2015·Journal of Molecular Neuroscience : MN·Karem H AlzoubiThomas Eissenberg
Oct 1, 2013·Biochimica Et Biophysica Acta·Emanuel Kennedy-FeitosaSamuel Santos Valenca
Dec 6, 2011·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Roberto Soares de MouraSamuel Santos Valenca
Jun 6, 2012·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Karla Maria Pereira PiresLuís Cristóvão Porto
Apr 5, 2011·Respiratory Physiology & Neurobiology·Frank Silva BezerraWalter Araujo Zin
Dec 29, 2010·Respiratory Physiology & Neurobiology·Karla Maria Pereira PiresSamuel Santos Valença
Sep 23, 2014·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Pinar KuruOzgur Kasimay
Mar 1, 2012·Molecular Immunology·Neeraj Singh, Liwu Li
Aug 8, 2013·Cellular Immunology·Keila Karine Duarte CamposFrank Silva Bezerra
May 27, 2014·Journal of Chromatographic Science·Katarzyna KowalskaHalina Milnerowicz
Oct 12, 2016·Biological Trace Element Research·Lv-Hui SunYu-Lan Liu
Mar 24, 2017·Inhalation Toxicology·Nour A Al-SawalhaNidal A Qinna
Jan 29, 2013·Experimental Biology and Medicine·Abderrahim NemmarErnest Adeghate
Jul 12, 2013·Bioinformatics and Biology Insights·Jurjen W WestraManuel C Peitsch
Mar 20, 2016·American Journal of Physiology. Lung Cellular and Molecular Physiology·P Padmini S J KhedoePieter S Hiemstra
Mar 23, 2018·Scientific Reports·Máira Tereza Talma ChíricoRodrigo Cunha de Menezes
Mar 18, 2015·Physiological Reports·Abderrahim NemmarErnest Adeghate

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