Oxidative Stress in Patients Undergoing Peritoneal Dialysis: A Current Review of the Literature

Oxidative Medicine and Cellular Longevity
Vassilios LiakopoulosPeter R Mertens

Abstract

Peritoneal dialysis (PD) patients manifest excessive oxidative stress (OS) compared to the general population and predialysis chronic kidney disease patients, mainly due to the composition of the PD solution (high-glucose content, low pH, elevated osmolality, increased lactate concentration and glucose degradation products). However, PD could be considered a more biocompatible form of dialysis compared to hemodialysis (HD), since several studies showed that the latter results in an excess accumulation of oxidative products and loss of antioxidants. OS in PD is tightly linked with chronic inflammation, atherogenesis, peritoneal fibrosis, and loss of residual renal function. Although exogenous supplementation of antioxidants, such as vitamins E and C, N-acetylcysteine, and carotenoids, in some cases showed potential beneficial effects in PD patients, relevant recommendations have not been yet adopted in everyday clinical practice.

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Citations

Dec 4, 2019·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Teppei OkamotoChikara Ohyama
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Feb 19, 2019·Oxidative Medicine and Cellular Longevity·Vassilios LiakopoulosEvangelia Dounousi
Apr 9, 2020·Frontiers in Cell and Developmental Biology·Julia CarracedoRafael Ramírez
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Oct 9, 2021·Medical Molecular Morphology·Hiro InoueTomoya Nishino

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Methods Mentioned

BETA
biopsies
MDA

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