Oxidative Stress in Shiga Toxin Production by Enterohemorrhagic Escherichia coli

Oxidative Medicine and Cellular Longevity
Katarzyna LicznerskaGrzegorz Węgrzyn

Abstract

Virulence of enterohemorrhagic Escherichia coli (EHEC) strains depends on production of Shiga toxins. These toxins are encoded in genomes of lambdoid bacteriophages (Shiga toxin-converting phages), present in EHEC cells as prophages. The genes coding for Shiga toxins are silent in lysogenic bacteria, and prophage induction is necessary for their efficient expression and toxin production. Under laboratory conditions, treatment with UV light or antibiotics interfering with DNA replication are commonly used to induce lambdoid prophages. Since such conditions are unlikely to occur in human intestine, various research groups searched for other factors or agents that might induce Shiga toxin-converting prophages. Among other conditions, it was reported that treatment with H2O2 caused induction of these prophages, though with efficiency significantly lower relative to UV-irradiation or mitomycin C treatment. A molecular mechanism of this phenomenon has been proposed. It appears that the oxidative stress represents natural conditions provoking induction of Shiga toxin-converting prophages as a consequence of H2O2 excretion by either neutrophils in infected humans or protist predators outside human body. Finally, the recently proposed b...Continue Reading

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Citations

Mar 15, 2018·Journal of Enzyme Inhibition and Medicinal Chemistry·Sylwia BlochGrzegorz Węgrzyn
Jun 6, 2018·Frontiers in Microbiology·Shuyang SunDiane McDougald
Jun 8, 2018·Frontiers in Medicine·Andrzej GórskiGrzegorz Węgrzyn
Sep 26, 2020·Frontiers in Molecular Biosciences·Katarzyna KozłowskaGrzegorz Węgrzyn
Apr 20, 2021·Frontiers in Microbiology·Ann-Katrin LlarenaToril Lindbäck
May 13, 2021·Journal of the American Chemical Society·Magdalena Jancheva, Thomas Böttcher
May 22, 2021·Frontiers in Microbiology·Grzegorz Węgrzyn, Maite Muniesa
May 30, 2021·The Journal of Pharmacy and Pharmacology·Sudhanshu SharmaPravir Kumar
Nov 30, 2016·New Biotechnology·Francesca MartaniPaola Branduardi

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