Oxidative stress in systemic lupus erythematosus: relationship to Th1 cytokine and disease activity

Immunology Letters
Dilip ShahArchana Bhatnagar

Abstract

Imbalance between oxidative stress and helper T-cell (Th1)-derived cytokines is one possible cause for the pathogenesis of systemic lupus erythematosus (SLE). To evaluate the correlation between oxidative stress and Th1 cytokine level with the disease activity of SLE in the North Indian population, oxidative/anti-oxidant profiles: malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione (GSH) and interferon (IFN)-gamma, interleukin (IL)-12 were studied. The estimation of oxidant and anti-oxidant enzymes was done in erythrocyte hemolysate and the levels of IFN-gamma and IL-12 were determined in the culture supernatant of peripheral blood mononuclear cells (PBMC) by a sandwich enzyme-linked immunosorbent assay (ELISA). A significant increase in the level of lipid peroxidation, measured as malondialdehyde (MDA), was found in SLE patients. The activities of anti-oxidant enzymes: SOD, CAT, GPx and anti-oxidant molecule GSH were significantly reduced in SLE patients as compared to controls. Increased levels of IFN-gamma and IL-12 were found in the culture supernatant of PBMC of SLE patients. MDA level was positively correlated with Systemic Lupus Erythematosus Disease Activity Index...Continue Reading

References

Jan 1, 1978·Methods in Enzymology·J A Buege, S D Aust
Jan 1, 1997·Free Radical Biology & Medicine·S TúriJ Nagy
Apr 18, 1998·Proceedings of the National Academy of Sciences of the United States of America·J D PetersonC Waltenbaugh
Aug 14, 1999·Arthritis and Rheumatism·M AkahoshiY Niho
Sep 21, 2002·Clinical Chemistry and Laboratory Medicine : CCLM·Seyithan TaysiNuri Bakan
Feb 28, 2003·Clinical and Experimental Immunology·H AhsanR Ali
Jul 24, 2003·Life Sciences·Biji T Kurien, R Hal Scofield
Jun 19, 2004·International Reviews of Immunology·Andras PerlKatalin Banki
Jul 5, 2008·Autoimmunity Reviews·Elena OrtonaWalter Malorni
Jul 16, 2008·Autoimmunity Reviews·F L Crane, H Low
Jul 22, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Masayoshi HarigaiNobuyuki Miyasaka
Sep 18, 2008·Clinical and Experimental Immunology·M TucciF Silvestris
Sep 20, 2008·Journal of Pharmacy & Pharmaceutical Sciences : a Publication of the Canadian Society for Pharmaceutical Sciences, Société Canadienne Des Sciences Pharmaceutiques·K TewthanomD Panomvana
Dec 20, 2008·Free Radical Research·Philip E MorganMichael J Davies
Jan 27, 2009·Biological Chemistry·Nazzareno BallatoriChristine L Hammond
Apr 10, 2009·Current Molecular Medicine·Elaine V Lourenço, Antonio La Cava
Apr 28, 2009·Autoimmunity Reviews·Carlo PerriconeRoberto Perricone

❮ Previous
Next ❯

Citations

Mar 12, 2011·Antioxidants & Redox Signaling·Valerio Chiurchiù, Mauro Maccarrone
Sep 4, 2012·Antioxidants & Redox Signaling·Pravin KesarwaniShikhar Mehrotra
Mar 19, 2014·Journal of Biomedical Science·Dilip ShahBishnuhari Paudyal
Mar 13, 2014·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Xiaosha Pang, Jun Panee
Jan 3, 2013·Autoimmunity Reviews·Dilip ShahSwapan K Nath
Mar 4, 2014·Journal of Autoimmunity·Deborah L HodgeHoward A Young
Dec 25, 2015·Nature Reviews. Rheumatology·Andras Perl
Dec 17, 2014·Molecular Neurobiology·Srdjan Ljubisavljevic
Aug 3, 2013·Journal of Cellular and Molecular Medicine·Tsai-Ching HsuBor-Show Tzang
Jan 17, 2014·International Journal of Rheumatic Diseases·Ki-Jo KimChul-Soo Cho
Nov 26, 2013·Journal of the Neurological Sciences·Srdjan LjubisavljevicDusica Pavlovic
Mar 29, 2019·JCI Insight·Maarten M SteinzJohanna T Lanner
Jan 13, 2012·Annals of the New York Academy of Sciences·Mindy S Lo, George C Tsokos
May 3, 2012·Arthritis and Rheumatism·Gabriela J GorelikBruce C Richardson
Aug 5, 2018·The Journal of Pharmacology and Experimental Therapeutics·Erifili HatziagelakiTheoharis C Theoharides
Nov 11, 2014·Reviews in the Neurosciences·Srdjan Ljubisavljevic, Ivana Stojanovic
Feb 11, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shulin QinTodd A Reinhart

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.