Oxidative Stress in the Healthy and Wounded Hepatocyte: A Cellular Organelles Perspective

Oxidative Medicine and Cellular Longevity
Tommaso MelloAndrea Galli

Abstract

Accurate control of the cell redox state is mandatory for maintaining the structural integrity and physiological functions. This control is achieved both by a fine-tuned balance between prooxidant and anti-oxidant molecules and by spatial and temporal confinement of the oxidative species. The diverse cellular compartments each, although structurally and functionally related, actively maintain their own redox balance, which is necessary to fulfill specialized tasks. Many fundamental cellular processes such as insulin signaling, cell proliferation and differentiation and cell migration and adhesion, rely on localized changes in the redox state of signal transducers, which is mainly mediated by hydrogen peroxide (H2O2). Therefore, oxidative stress can also occur long before direct structural damage to cellular components, by disruption of the redox circuits that regulate the cellular organelles homeostasis. The hepatocyte is a systemic hub integrating the whole body metabolic demand, iron homeostasis and detoxification processes, all of which are redox-regulated processes. Imbalance of the hepatocyte's organelles redox homeostasis underlies virtually any liver disease and is a field of intense research activity. This review recapi...Continue Reading

References

Jul 1, 1979·Physiological Reviews·B ChanceA Boveris
Dec 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T HiranoJ C Fernandez-Checa
Feb 28, 1990·Biochemical and Biophysical Research Communications·K KurosawaK Tagawa
Sep 1, 1989·Gastroenterology·J C CollinsI Sternlieb
Jun 1, 1988·Biochemical Society Transactions·C S Lieber
Jul 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·O W Griffith, A Meister
Jul 1, 1972·The Biochemical Journal·A BoverisB Chance
Jan 1, 1994·Annual Review of Nutrition·J K Reddy, G P Mannaerts
Dec 14, 1995·Biochimica Et Biophysica Acta·K K KharbandaT M Donohue
Jan 3, 1997·Clinica Chimica Acta; International Journal of Clinical Chemistry·C S Lieber
May 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·A DenicolaR Radi
Sep 17, 1999·Journal of Hepatology·S H CaldwellW D Parker
Nov 13, 1999·Nature Cell Biology·J W Cuozzo, C A Kaiser
Jun 2, 2000·Biochemical and Biophysical Research Communications·J LegaultM E Mirault
Aug 15, 2000·Annual Review of Nutrition·C S Lieber
Dec 7, 2000·Biochimica Et Biophysica Acta·K Staniek, H Nohl
Jun 9, 2001·Antioxidants & Redox Signaling·A L LevonenV M Darley-Usmar
Aug 2, 2001·Proceedings of the National Academy of Sciences of the United States of America·G GongA Siddiqui
Aug 21, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S P ElmoreJ J Lemasters
Mar 28, 2002·The Journal of Biological Chemistry·Seung-Rock LeeSue Goo Rhee
Sep 19, 2002·The Journal of Biological Chemistry·Julie St-PierreMartin D Brand
Aug 27, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Olga CollJ C Fernández-Checa
Sep 27, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mercedes Pérez-CarrerasJosé A Solis-Herruzo
Oct 1, 2003·Molecular and Cellular Biology·Sara B CullinanJ Alan Diehl
Dec 20, 2003·Cell Death and Differentiation·S Oyadomari, M Mori
Jul 16, 2004·The Journal of Biological Chemistry·Seema Chakravarthi, Neil J Bulleid
Sep 8, 2004·Molecular Cell·Cole M HaynesAntony A Cooper
Sep 15, 2004·Journal of Chemical Neuroanatomy·Xiaohua ShenRandal J Kaufman
Oct 16, 2004·Science·Umut OzcanGökhan S Hotamisligil
Nov 10, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jaeyul KwonSue Goo Rhee
Jan 7, 2005·The Journal of Pharmacology and Experimental Therapeutics·Odile SergentDominique Lagadic-Gossmann

❮ Previous
Next ❯

Citations

May 5, 2017·International Journal of Molecular Sciences·Filippo CellaiMarco E M Peluso
Aug 26, 2017·World Journal of Gastroenterology : WJG·Xiao-Feng YanXiao-Ling Wang
Jan 25, 2017·PPAR Research·Tommaso MelloAndrea Galli
Jun 28, 2018·American Journal of Physiology. Cell Physiology·Elodie SaudraisJean-François Ghersi-Egea
Dec 22, 2019·Scientific Reports·Hakm Y MuradDamir B Khismatullin
Oct 13, 2020·Frontiers in Endocrinology·Jorge A Berlanga-AcostaPedro A Valdés-Sosa
Oct 7, 2020·Scientific Reports·Md Zahangir HosainYoshiki Katayama
Dec 22, 2020·Frontiers in Pharmacology·Cheng PengCheng Xue Qin
May 1, 2021·Antioxidants·Gregori CasalsWladimiro Jiménez
Jul 5, 2021·Environmental Science and Pollution Research International·Mohamed SeifZaizhao Wang
Mar 11, 2019·International Immunopharmacology·Miriam Viviane DiasRômulo Dias Novaes

❮ Previous
Next ❯

Methods Mentioned

BETA
protein folding
protein-folding
transgenic

Related Concepts

Related Feeds

Autophagy Networks

Autophagy is a lysosomal pathway that involves degradation of proteins and functions in normal growth and pathological conditions, through a series of complex networks. The catabolic process involves delivery of proteins and organelles to the lysosome. Here is the latest research on autophagy networks.

Adrenocortical Carcinoma

Hepatocellular carcinoma is the most common type of primary liver cancer and frequently occurs in individuals with chronic liver diseases like cirrhosis. Here is the latest research.

Autophagy & Aging: Inhibitors

The feed focuses on the role of nuclear export inhibitors and their effect on autophagy and the aging process.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

International Journal of Cardiology
Tiago Bittencourt de OliveiraDanilo Wilhelm Filho
The Lancet. Diabetes & Endocrinology
José Manuel Fernández-Real, Melania Manco
© 2022 Meta ULC. All rights reserved