Oxidative stress in the placenta

Histochemistry and Cell Biology
Leslie Myatt, Xiaolan Cui

Abstract

Pregnancy is a state of oxidative stress arising from increased placental mitochondrial activity and production of reactive oxygen species (ROS), mainly superoxide anion. The placenta also produces other ROS including nitric oxide, carbon monoxide, and peroxynitrite which have pronounced effects on placental function including trophoblast proliferation and differentiation and vascular reactivity. Excessive production of ROS may occur at certain windows in placental development and in pathologic pregnancies, such as those complicated by preeclampsia and/or IUGR, overpowering antioxidant defenses with deleterious outcome. In the first trimester, establishment of blood flow into the intervillous space is associated with a burst of oxidative stress. The inability to mount an effective antioxidant defense against this results in early pregnancy loss. In late gestation increased oxidative stress is seen in pregnancies complicated by diabetes, IUGR, and preeclampsia in association with increased trophoblast apoptosis and deportation and altered placental vascular reactivity. Evidence for this oxidative stress includes increased lipid peroxides and isoprostanes and decreased expression and activity of antioxidants. The interaction of n...Continue Reading

References

Jul 1, 1979·Physiological Reviews·B ChanceA Boveris
Sep 1, 1979·Cell and Tissue Research·P KaufmannG Schweikhart
Sep 1, 1979·Cell and Tissue Research·D K SenG Schweikhart
Jan 1, 1977·Biology of the Neonate·B K van Kreel, J P van Dijk
Nov 1, 1992·Archives of Biochemistry and Biophysics·H IschiropoulosJ S Beckman
Apr 1, 1992·Archives of Biochemistry and Biophysics·C A PartridgeA B Malik
Aug 1, 1991·Archives of Biochemistry and Biophysics·R RadiB A Freeman
Dec 1, 1991·American Journal of Obstetrics and Gynecology·S J WisdomJ J Walker
Feb 1, 1991·American Journal of Obstetrics and Gynecology·L MyattD E Brockman
Oct 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·D MaglioneM G Persico
Feb 1, 1990·Experimental Cell Research·B WiceA L Schwartz
Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J S BeckmanB A Freeman
Aug 1, 1990·American Journal of Obstetrics and Gynecology·P R GarnerM Hardie
Apr 25, 1989·Biochimica Et Biophysica Acta·M Wajner, R A Harkness
Nov 1, 1988·Journal of Applied Physiology·L S TeradaJ E Repine
Jan 1, 1995·American Journal of Respiratory Cell and Molecular Biology·J J ZuluetaP M Hassoun
Sep 21, 1995·Biochimica Et Biophysica Acta·P CaraceniA B Borle
Dec 20, 1994·Proceedings of the National Academy of Sciences of the United States of America·L M VillaS Moncada
Dec 1, 1994·The Journal of Clinical Investigation·I Y HaddadS Matalon
Feb 23, 1994·Molecular and Cellular Biochemistry·N CesterC Romanini
Feb 1, 1994·Biological Chemistry Hoppe-Seyler·J S BeckmannC R White
Jan 1, 1994·Archives of Biochemistry and Biophysics·R RadiR Telleri
Aug 1, 1996·Journal of Cellular Physiology·E AlsatD Evain-Brion
Jul 1, 1996·Placenta·A ManyJ M Roberts
Oct 1, 1996·The Journal of Clinical Investigation·M KurokiA P Adamis
Nov 1, 1996·The American Journal of Physiology·J S Beckman, W H Koppenol
Dec 1, 1996·Journal of Reproductive Immunology·Y Wang, S W Walsh
Jul 1, 1997·American Journal of Obstetrics and Gynecology·S C SmithE M Symonds
Sep 12, 1997·Science·O GenbacevS J Fisher
Oct 6, 1997·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·L MyattF Lyall

❮ Previous
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Citations

Jun 2, 2006·Naunyn-Schmiedeberg's Archives of Pharmacology·Federico Manuel DarayRodolfo Pedro Rothlin
Feb 24, 2011·Archives of Gynecology and Obstetrics·Habibe GencOnur Güralp
Dec 23, 2004·Histochemistry and Cell Biology·Esther Asan, Detlev Drenckhahn
Nov 12, 2005·Histochemistry and Cell Biology·Douglas J Taatjes, Jürgen Roth
Dec 7, 2006·Histochemistry and Cell Biology·Douglas J TaatjesJürgen Roth
Nov 1, 2007·Histochemistry and Cell Biology·Christian ZuberJürgen Roth
Apr 20, 2005·Virchows Archiv : an International Journal of Pathology·Maciej LopuckiMarta Kankofer
Feb 6, 2013·Medical Molecular Morphology·Takeshi KajiharaOsamu Ishihara
Nov 26, 2009·Journal of Molecular Neuroscience : MN·Shiva Nasiraei-MoghadamAbolhassan Ahmadiani
Jun 29, 2013·Reproductive Toxicology·João Ricardo AraújoFátima Martel
Mar 10, 2010·The British Journal of Nutrition·Corinna FrankeBerthold Koletzko
Mar 24, 2012·Animal : an International Journal of Animal Bioscience·C B Berchieri-RonchiA L A Ferreira
Aug 21, 2012·Pediatric Research·Brandon W AllemanUNKNOWN Norwegian Mother and Child Cohort Study (MoBA) Genome-Wide Association Study Group
Jan 8, 2009·Antioxidants & Redox Signaling·Joern R SteinertGiovanni E Mann
Jun 17, 2011·Antioxidants & Redox Signaling·Martha LappasAlicia Jawerbaum
Jan 14, 2012·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Cleofina Bosco, Eugenia Diaz
Jun 7, 2008·Human Reproduction Update·Elizabeth H RuderMarlene B Goldman
Jan 14, 2011·Biology of Reproduction·Hong-hai ZhangDong-bao Chen
Sep 9, 2009·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Mark J NieuwenhuijsenMireille Toledano
Sep 16, 2011·Oxidative Medicine and Cellular Longevity·Hiten D Mistry, Paula J Williams
Jan 24, 2008·Reproductive Sciences·Eugenia Mata-Greenwood, Dong-Bao Chen
Jul 4, 2012·Reproductive Biology and Endocrinology : RB&E·Ashok AgarwalSajal Gupta
Jul 16, 2005·Reproductive Biology and Endocrinology : RB&E·Ashok AgarwalRakesh K Sharma
Feb 10, 2007·Reproductive Biology and Endocrinology : RB&E·Laura LunghiFortunato Vesce

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