Oxidative stress in viral hepatitis and AIDS

Experimental and Molecular Pathology
William E Stehbens

Abstract

Dominant types of viral hepatitis are presently A, B, and C with prophylactic immunization available only for A and B. Hepatitis B and C and human immunodeficiency virus (HIV) infection constitute a worldwide scourge and treatment is far from satisfactory. Each produces severe oxidative stress (OS) and secondary cellular damage of varying severity and, as in toxic hepatitis, progression and regression are dependent on redox balance between oxidation and antioxidation. Experimental and clinical studies suggest that xenobiotics and co-infections exert cumulative, detrimental effects on their pathogeneses and further deplete antioxidants. It is proposed therefore that in the clinical management of these infections and especially in their early stages, considerable benefit should accrue from antioxidant repletion at dosages substantially above recommended daily allowances (RDAs) in conjunction with a nutritious high protein diet. Because plasma zinc and selenium concentrations are very low, their replenishment by high dosages is urgent and mandatory particularly in advanced HIV infections bordering on acrodermatitis enteropathica. Also recommended is their long-term continuance at high normal levels.

References

May 1, 1979·The Medical Clinics of North America·C H Tamburro
Feb 1, 1976·Annals of Internal Medicine·J R MitchellS D Nelson
Apr 11, 1992·Lancet·F J StaalL A Herzenberg
Sep 30, 1992·Annals of the New York Academy of Sciences·S N MeydaniL Coleman
Jan 1, 1992·Journal of Gastroenterology and Hepatology·T ShigesawaF Marumo
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S HarakehL Pauling
Feb 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·T KalebicA S Fauci
Jan 1, 1990·Journal of Hepatology·F DianzaniM R Capobianchi
Jan 1, 1990·Journal of Hepatology·H C Thomas
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M RoedererL A Herzenberg
Sep 1, 1990·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·B VandercamM E Lamy
Nov 30, 1989·Biochemical and Biophysical Research Communications·S R GoguK C Agrawal
Dec 1, 1987·Environmental Health Perspectives·J G Lewis, D O Adams
Feb 12, 1988·JAMA : the Journal of the American Medical Association·N FabrisM Moroni
Feb 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·H PopperJ L Gerin
Jul 1, 1973·Proceedings of the Society for Experimental Biology and Medicine·J E SpallholzR H Heinzerling
May 1, 1974·Proceedings of the Society for Experimental Biology and Medicine·R H HeinzerlingR P Tengerdy
Jun 5, 1982·British Medical Journal·A Ilchyshyn, S Mendelsohn
May 24, 1995·Biochimica Et Biophysica Acta·L Ernster, G Dallner
Jan 1, 1995·Annual Review of Immunology·F V Chisari, C Ferrari
Dec 20, 1994·Proceedings of the National Academy of Sciences of the United States of America·T M HagenF V Chisari
Jan 1, 1994·Immunology Today·T M Buttke, P A Sandstrom
Jan 14, 1994·Clinica Chimica Acta; International Journal of Clinical Chemistry·D J MalvyO Amédée-Manesme
Jun 1, 1994·Chemico-biological Interactions·A FavierM Micoud
Dec 1, 1993·Journal of Clinical Epidemiology·W E Stehbens
Jun 1, 1993·The British Journal of Surgery·P ScottR F McCloy
Jan 1, 1993·Physiological Reviews·B L Vallee, K H Falchuk
Dec 1, 1995·Free Radical Biology & Medicine·J FuchsR Milbradt
Jul 15, 1996·Annals of Internal Medicine·A S Prasad
Jan 1, 1996·Free Radical Biology & Medicine·N De MariaR A Floyd
Jan 1, 1996·Free Radical Biology & Medicine·K B Schwarz
Jan 1, 1997·Biological Trace Element Research·E Peterhans
Jan 1, 1997·Nutrition Reviews·B Halliwell
Jan 1, 1997·Molecular Aspects of Medicine·F L Crane, P Navas
Jan 1, 1997·Molecular Aspects of Medicine·Y Yamamoto, S Yamashita
Aug 1, 1997·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·I CakmanL Rink
Aug 15, 1997·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·M K BaumJ B Page
Dec 5, 1997·Immunology Today·N WellinghausenL Rink

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Citations

Mar 25, 2014·World Journal of Gastroenterology : WJG·Shiu-Wan Chan
Jun 25, 2005·Journal of the American Society of Nephrology : JASN·Michael J RossLeslie A Bruggeman
Dec 13, 2006·Journal of Occupational Medicine and Toxicology·Anke van MarkElke Brinkmann
Apr 29, 2008·AIDS Research and Therapy·Jeffrey S OtisDavid M Guidot
Oct 3, 2009·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Abhishek SrivastavaB Kevin Park
Jan 18, 2011·Antioxidants & Redox Signaling·Ingolf E BlasigReiner F Haseloff
Apr 7, 2007·Digestive Diseases and Sciences·Ioannis StamoulisStamatios Theocharis
Jan 6, 2011·Expert Opinion on Biological Therapy·Manish K JohriSunit K Singh
Aug 4, 2011·Clinics and Research in Hepatology and Gastroenterology·Manouchehr NakhjavaniHossein Froutan
Jun 18, 2010·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Leila GangeheiMehran Haidari
Jul 16, 2010·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Robert SchwartzHerve Y Sroussi
May 12, 2009·Free Radical Biology & Medicine·Raymond C S SeetBarry Halliwell
May 5, 2009·Free Radical Biology & Medicine·Hong-Sheng ZhangHong-Sen Zhou
Jul 11, 2008·International Journal of Dermatology·David James NajarianAmy S Pappert
Apr 12, 2012·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Runzhi ZhuQinglong Guo
May 17, 2011·Alcoholism, Clinical and Experimental Research·Xian FanDavid M Guidot
May 6, 2015·European Journal of Medicinal Chemistry·Aurelia Magdalena Pisoschi, Aneta Pop
Apr 8, 2015·The International Journal of Biochemistry & Cell Biology·Kadiam C Venkata SubbaiahRajagopal Subramanyam
Nov 17, 2012·The International Journal of Biochemistry & Cell Biology·Xin-Yu ChenZheng Ruan
Mar 4, 2014·BioMed Research International·Anu RahalKuldeep Dhama
Jul 20, 2014·Fish & Shellfish Immunology·Yi YangJunfa Yuan
Dec 3, 2013·Journal of Sports Sciences·Alesandro GarciaFabricio Azevedo Voltarelli
Oct 23, 2016·Fish & Shellfish Immunology·Junhui ShaoJunfa Yuan
Jan 21, 2017·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Mar MasiáUNKNOWN CoRIS
Oct 25, 2006·Journal of Enzyme Inhibition and Medicinal Chemistry·Leixiang YangYu Zhao
Jan 7, 2018·Antioxidants & Redox Signaling·Sebastian Öther-Gee PohlShazib Pervaiz
Mar 13, 2019·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Vitor H F OliveiraRafael Deminice
Dec 4, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Takashi AndoRolf Kiessling

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