Oxidative stress increases 6-nitronorepinephrine and 6-nitroepinephrine concentrations in rat brain

Biomedical Chromatography : BMC
Makoto TsunodaTakashi Funatsu

Abstract

6-Nitronorepinephrine (nitroNE) and 6-nitroepinephrine (nitroE) are reaction products of nitric oxide and norepinephrine and epinephrine, respectively. The authors have previously reported a method for determination of nitroNE and nitroE in rat brain using high-performance liquid chromatography-peroxyoxalate chemiluminescence reaction detection. In this study, the effect of oxidative stress on nitroNE and nitroE concentrations in rat brain was examined using this method. After kainic acid administration in rats for 2 days, the concentrations of both nitroNE and nitroE in rat brains were found to have increased by 400-600%, which was partly suppressed by the co-administration of a superoxide dismutase mimetic. This indicates that oxidative stress might increase nitroNE and nitroE concentrations in rat brains.

References

Jun 7, 1996·The Journal of Biological Chemistry·F ShintaniT Nakaki
Jun 1, 1997·Nitric Oxide : Biology and Chemistry·C DaveuC Ducrocq
Mar 31, 2005·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Yoko HiranoKazuhiro Imai
Jun 15, 2005·Molecular Neurobiology·Qun WangAlbert Y Sun
Aug 23, 2006·Analytical and Bioanalytical Chemistry·Makoto Tsunoda
Jan 26, 2007·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Hiroshi HasegawaIssei Komuro

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