PMID: 9547356May 9, 1998Paper

Oxidative stress increases A1 adenosine receptor expression by activating nuclear factor kappa B

Molecular Pharmacology
Z NieVickram Ramkumar

Abstract

The A1 adenosine receptor (A1AR) contributes to the cytoprotective action of adenosine under conditions known to generate reactive oxygen species (ROS). Pharmacological manipulation of A1AR expression has been shown to modulate this cytoprotective role. In this study, we provide evidence that ROS generated could increase the expression of the A1AR and thereby offset the detrimental effects of ROS. Incubation of DDT1MF-2 smooth muscle cells with ROS-generating chemotherapeutic agents, such as cisplatin (2.5 microM) or H2O2 (10 microM), elicited an increase in A1AR expression within 24 hr. The induction by H2O2 was reduced by the ROS scavenger catalase but not superoxide dismutase. Inhibition of nuclear factor kappa B (NF kappa B) by pyrrolidine dithiocarbamate (200 microM), dexamethasone (100 nM), or genistein (1 microM) abrogated the cisplatin-mediated increase in A1AR. Cisplatin promoted rapid translocation of NF kappa B (but not AP-1) to the nucleus, as detected by electrophoretic mobility shift assays and by Western blotting. A putative NF kappa B sequence in the A1AR promoter effectively competed with labeled kappa B probe for binding in nuclear preparations derived from DDT1MF-2 cells. Transient transfection of DDT1MF-2 ce...Continue Reading

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Citations

Aug 12, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·T KubotaJ M Krueger
Jul 27, 2005·Molecular Carcinogenesis·Manickam VenkatramanDevarajan Karunagaran
Dec 3, 2005·The Journal of Pharmacology and Experimental Therapeutics·Sarvesh JajooVickram Ramkumar
Oct 12, 2007·Transplant International : Official Journal of the European Society for Organ Transplantation·Olga S León FernándezAnna M Carmona
Oct 16, 2009·American Journal of Physiology. Cell Physiology·Sarvesh JajooVickram Ramkumar
Aug 21, 2013·Journal of Thyroid Research·Gabriel Fernandes SilveiraAlessandra Nejar Bruno
Jan 31, 2014·International Journal of Molecular Sciences·Sandeep ShethVickram Ramkumar
Nov 18, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anacharis B de Sá-NakanishiAdelar Bracht
May 30, 2019·International Journal of Molecular Sciences·Yaara Gorzalczany, Ronit Sagi-Eisenberg
Mar 7, 2001·Hypertension·L O LermanJ C Romero
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