Oxidative stress-induced inflammation in susceptible airways by anthropogenic aerosol

PloS One
Zaira LeniMarianne Geiser

Abstract

Ambient air pollution is one of the leading five health risks worldwide. One of the most harmful air pollutants is particulate matter (PM), which has different physical characteristics (particle size and number, surface area and morphology) and a highly complex and variable chemical composition. Our goal was first to comparatively assess the effects of exposure to PM regarding cytotoxicity, release of pro-inflammatory mediators and gene expression in human bronchial epithelia (HBE) reflecting normal and compromised health status. Second, we aimed at evaluating the impact of various PM components from anthropogenic and biogenic sources on the cellular responses. Air-liquid interface (ALI) cultures of fully differentiated HBE derived from normal and cystic fibrosis (CF) donor lungs were exposed at the apical cell surface to water-soluble PM filter extracts for 4 h. The particle dose deposited on cells was 0.9-2.5 and 8.8-25.4 μg per cm2 of cell culture area for low and high PM doses, respectively. Both normal and CF HBE show a clear dose-response relationship with increasing cytotoxicity at higher PM concentrations. The concurrently enhanced release of pro-inflammatory mediators at higher PM exposure levels links cytotoxicity to ...Continue Reading

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Citations

Apr 12, 2021·Environmental Health : a Global Access Science Source·Patrick D M C KatotoBenoit Nemery
Nov 20, 2020·Nature·Kaspar R DaellenbachAndré S H Prévôt
Aug 15, 2021·The Science of the Total Environment·Pedro TrecheraXavier Querol

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