Oxidative stress-inducible protein tyrosine phosphatase in glomerulonephritis

Kidney International
L FengC B Wilson

Abstract

Previously we found that rat mesangial cells express 3CH134/CL100 protein-tyrosine phosphatase (PTPase) in response to reactive oxygen intermediates (ROIs), and we now extend these studies to glomerulonephritis (GN), where ROI have been demonstrated to play a role. The rat homologue of 3CH134/CL100 was cloned from a rat macrophage cDNA library. The rat 3CH134/CL100 mRNA was strongly induced in the lung, liver, and heart the first day after birth, suggesting that hyperoxic adaption might be involved in the induction of the PTPase mRNA. In anti-glomerular basement membrane (GBM) antibody (Ab) GN in rats, the 3CH134/CL100 PTPase mRNA was expressed in glomeruli as early as 30 minutes after anti-GBM Ab injection. The 3CH134/CL100 mRNA expression was modulated by the ROI scavenger dimethylthiourea (DMTU), indicating that its induction was ROI related. In contrast to the glomerular lesion, PTPase mRNA expression was not induced in experimental tubulointerstitial nephritis. In situ hybridization suggested that mesangial and some infiltrating cells were the major glomerular cell sources of the PTPase mRNA. These results indicate that rat CCH134/CL100 PTPase is actively induced in glomeruli as part of an acute immune injury at least in p...Continue Reading

References

Oct 1, 1976·The Journal of Clinical Investigation·R C Blantz, C B Wilson
Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·T IshibashiS A Aaronson
Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·K GuanJ E Dixon
Mar 1, 1992·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J R Diamond
Jul 22, 1992·Biochimica Et Biophysica Acta·D A Pot, J E Dixon
Mar 28, 1991·Nature·K L GuanJ E Dixon
May 1, 1991·Molecular and Cellular Biology·Y DevaryM Karin
Feb 1, 1990·Trends in Biochemical Sciences·M Baggiolini, M P Wymann
Mar 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·L F Lau, D Nathans
Mar 16, 1995·Biochimica Et Biophysica Acta·S M Keyse
Apr 1, 1994·Kidney International·W W TangC B Wilson
Jul 1, 1993·British Medical Bulletin·L Baud, R Ardaillou
Dec 1, 1993·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J N Wilcox
Oct 1, 1993·Trends in Biochemical Sciences·S M Keyse, M Ginsburg
May 1, 1993·Journal of the American Society of Nephrology : JASN·L FengC B Wilson
Mar 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·R DattaD W Kufe
Apr 1, 1993·Trends in Biochemical Sciences·E Nishida, Y Gotoh
Jun 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·C H CharlesN K Tonks
Sep 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·G PagèsJ Pouysségur
Apr 30, 1993·Biochemical and Biophysical Research Communications·L FengC B Wilson

❮ Previous
Next ❯

Citations

Dec 19, 2000·Biochemical and Biophysical Research Communications·Y Ishikawa, M Kitamura
Apr 3, 2004·Free Radical Biology & Medicine·Qihe XuMasanori Kitamura
May 7, 1999·Kidney International·M Kitamura, L G Fine
Aug 1, 1997·The Journal of Clinical Investigation·D BokemeyerM J Dunn
Sep 11, 1998·Developmental Dynamics : an Official Publication of the American Association of Anatomists·D C TanneyD H Lovett
Mar 17, 1998·Archives of Biochemistry and Biophysics·F SchliessD Häussinger

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.