Oxidative stress, inflammation and early cardiovascular damage in children with chronic renal failure

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Aydin EceSahbettin Selek

Abstract

The relationship between inflammation, oxidant stress and cardiovascular damage in children with chronic renal failure (CRF) has not previously been investigated. The aim of this study was to investigate markers of oxidative stress, inflammation and early cardiovascular abnormalities. Therefore, erythrocyte superoxide dismutase (SOD) and catalase (CAT) activities; blood glutathione (GSH) and serum malondialdehyde (MDA) levels; C-reactive protein (CRP) and proinflammatory cytokines (IL-6, TNF-alpha,); and left ventricular masses (LVM) and intima media thicknesses (IMT) were measured in children with CRF. A total of 29 children with CRF (19 nondialysis, 10 peritoneal dialysis) were included. The control group consisted of 25 healthy subjects. CRF children had significantly increased IL-6, TNF-alpha, CRP and MDA concentrations and decreased SOD, CAT and GSH levels compared with controls (P<0.05). Nondialysis and peritoneal dialysis subgroups had similar oxidative stress and inflammation biomarkers (P>0.05). Erythrocyte CAT was positively correlated with CRP, TNF-alpha, and IL2-R in the study group. Positive correlations were found between cytokine concentrations, CRP and urea/creatinine levels. Significantly increased LVM and IMT ...Continue Reading

References

Jan 1, 1990·Free Radical Biology & Medicine·K AsayamaK Kato
Jan 1, 1965·Advances in Clinical Chemistry·E J Van Kampen, W G Zijlstra
Jan 1, 1984·Methods in Enzymology·H Aebi
Jun 26, 2001·Kidney International·J Himmelfarb, E McMonagle
Jun 28, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·G EniaC Zoccali
Sep 29, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·T QuaschningC Wanner
Jan 15, 2002·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·D KonukogluS Onen
Apr 23, 2002·Hypertension·Jonathan M SorofRonald J Portman
Oct 10, 2002·Kidney International·Jonathan HimmelfarbRaymond M Hakim
Dec 11, 2002·Kidney International·Nosratola D VaziriRam K Sindhu
May 31, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Roberto Pecoits-FilhoPeter Stenvinkel
Jun 17, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Francesco LocatelliCarmine Zoccali
Jun 5, 2004·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Danuta ZwolińskaMaria Szczepańska
Sep 14, 2004·Nephron. Clinical Practice·Sabine H A DiepeveenAnton F H Stalenhoef
Dec 16, 2004·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Rulan S Parekh, Samuel S Gidding
Apr 6, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jacek ZachwiejaAldona Siwińska
Jun 9, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Aydin EceMurat Tutanç
Sep 1, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Lyonne K van RossumArnold G Vulto
Oct 28, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Aydin EceAli Güneş

❮ Previous
Next ❯

Citations

Apr 4, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Aydin EceOzcan Erel
Oct 30, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Nurcan CengizMehmet Haberal
Nov 3, 2012·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jelena Kotur-StevuljevićDanijela Kornic-Ristovski
Jun 7, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Ylva Tranæus LindbladPeter Bárány
Jan 30, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Denise MafraMaurilo Leite
Jun 30, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Maurizio BruschiEnrico Verrina
Apr 14, 2010·Journal of Veterinary Internal Medicine·R F Keegan, C B Webb
Dec 5, 2009·Critical Reviews in Clinical Laboratory Sciences·Daniela GiustariniRanieri Rossi
Feb 27, 2016·Advanced Biomedical Research·Mohammad Reza SabriAlaleh Gheissari
Apr 3, 2012·Clinical Biochemistry·Mustafa Kasım KarahocagilAbdullah Taskın
Dec 22, 2015·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology·Hanan H KamelGhada A Saad
May 22, 2010·Pediatrics International : Official Journal of the Japan Pediatric Society·Bozena PolańskaAdam Jankowski
Jun 12, 2013·Redox Report : Communications in Free Radical Research·Huseyin BegenikMehmet Aslan
Jun 1, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Badrinathan SridharanPragasam Viswanathan
Aug 21, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Stuart L GoldsteinDouglas M Silverstein
Jan 19, 2010·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Kinga MusialDanuta Zwolińska
Jun 15, 2019·International Urology and Nephrology·Elżbieta Cecerska-HeryćBarbara Dołęgowska
Jul 7, 2017·Journal of Medical Biochemistry·Danijela Ristovski-KornicZorana Jelić-Ivanović

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Related Papers

Infection and Immunity
J A KimJ E Mayfield
International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
Leman KaraagacNurten Aksoy
Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Aydin EceAli Güneş
© 2021 Meta ULC. All rights reserved