Oxidative stress, inflammation, and markers of cardiovascular health

Atherosclerosis
Sindhu LakkurMichael Goodman

Abstract

To investigate associations of a oxidative balance score (OBS) with blood levels of total cholesterol, low-density lipoprotein- (LDL)-cholesterol, high-density lipoprotein- (HDL) cholesterol and triglycerides, and biomarkers of inflammation (serum C-reactive protein [CRP], albumin and venous total white blood cell [WBC] counts) among 19,825 participants in a nationwide study. Using cross-sectional data 14 dietary and lifestyle components were incorporated into the OBS and the resulting score (range 3-26) was then divided into five equal intervals. Multivariable-adjusted odds ratios (ORs) for abnormal biomarker levels and 95% confidence intervals (CIs) were calculated using logistic regression models. The ORs (95% CIs) comparing those in the highest relative to those in the lowest OBS equal interval categories were 0.50 (0.38-0.66) for CRP, 0.50 (0.36-0.71) for the total WBC count, and 0.75 (0.58-0.98) for LDL-cholesterol; all three p-values for trend were <0.001. The OBS-HDL-cholesterol association was statistically significantly inverse among females, but not among males. The OBS was not associated with serum albumin or triglycerides. Our findings suggest that an OBS may be associated with some, but not all, circulating lipids...Continue Reading

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Citations

Feb 14, 2017·Oxidative Medicine and Cellular Longevity·Ho-Sun Lee, Taesung Park
Jan 11, 2018·Clinical and Experimental Pharmacology & Physiology·Jeong-Seok KimHo-Keun Yi
Jun 25, 2019·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·Mona GolmohammadiRasoul Zarrin
Dec 31, 2019·Oxidative Medicine and Cellular Longevity·Martha A Sánchez-Rodríguez, Víctor Manuel Mendoza-Núñez
Jun 26, 2020·Frontiers in Cell and Developmental Biology·Wanjun MaWenqun Li
Apr 2, 2019·Oxidative Medicine and Cellular Longevity·Ho-Sun LeeTaesung Park
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Jul 1, 2021·Oxidative Medicine and Cellular Longevity·Zahra NoruziSakineh Shab-Bidar

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