Oxidative stress influence on renal dysfunction in patients with obstructive jaundice: A case and control prospective study

Redox Biology
David Martínez-CeciliaF J Padillo

Abstract

Obstructive Jaundice (OJ) is associated with a significant risk of developing acute renal failure (ARF). The involvement of oxidative stress in the development of cholestasis has been demonstrated in different experimental models. However, its role in the morbidity of human cholestasis is far to be elucidated. The aim of the study was the evaluation of oxidative stress markers in blood from patients with OJ and its relation to complications and benign/malignant evolution of cholestasis. A prospective cross-sectional study of 105 patients with OJ and 34 control subjects were included. Several markers of liver function and oxidative stress, such as lipoperoxides (LPO), as well as reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities were assessed. The patients with OJ showed a marked increase in plasma levels of LPO, SOD and GSH, while GSH-Px levels were decreased. The increase in lipid peroxidation products and the depletion of SOD activity in blood were also related to renal dysfunction. The highest level of LPO was associated with malignant etiology of the disease. The logistic regression analysis showed that the age of the patient and the levels of LPO in blood we...Continue Reading

References

Jun 1, 1992·The British Journal of Surgery·A Sitges-SerraJ M Gubern
Sep 1, 1971·The Journal of Surgical Research·D J Gillett
Jul 1, 1995·The British Journal of Surgery·B J FogartyT Diamond
Dec 1, 1995·The British Journal of Surgery·O M Jolobe
Mar 27, 1998·HPB Surgery : a World Journal of Hepatic, Pancreatic and Biliary Surgery·S YüceyarY Kafadar
Jul 3, 1999·World Journal of Surgery·F J PadilloC Pera-Madrazo
Aug 15, 2001·European Journal of Pharmacology·A CruzP Montilla
May 13, 2003·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·C KucukS Muhtaroglu
Aug 1, 1960·Archives of Surgery·R D WILLIAMSR M ZOLLINGER
Aug 2, 2005·Journal of Pediatric Gastroenterology and Nutrition·Ronald J SokolEric Gumpricht
Aug 4, 2005·The British Journal of Surgery·F J PadilloA Sitges-Serra
Aug 16, 2006·Annals of Internal Medicine·Andrew S LeveyUNKNOWN Chronic Kidney Disease Epidemiology Collaboration
Jul 24, 2008·Redox Report : Communications in Free Radical Research·Stelios F AssimakopoulosChristos Georgiou
Jul 28, 2009·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·F J PadilloJ Muntané

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Citations

Nov 7, 2019·Annals of Surgical Oncology·Bofeng ChenCharles M Vollmer
Jan 14, 2017·World Journal of Gastroenterology : WJG·Gloria SegarraPascual Medina
Apr 5, 2019·JFMS Open Reports·Luís Hg SaraivaRoselene Ecco
Jun 9, 2020·Stress : the International Journal on the Biology of Stress·Mohammad Mehdi OmmatiReza Heidari
Nov 28, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Jiayue LiuGuixin Zhang
Feb 5, 2021·Naunyn-Schmiedeberg's Archives of Pharmacology·Mohammad Mehdi OmmatiReza Heidari
Nov 8, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Jinming ZhangJialan Shi
Nov 6, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Reza HeidariHossein Niknahad

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