Oxidative stress injury in doxorubicin-induced cardiotoxicity

Toxicology Letters
Mei SongboShao Liang

Abstract

Doxorubicin (DOX) is widely used as a broad-spectrum anti-tumor anthracycline to treat various cancers. The serious adverse effects of DOX on cardiotoxicity limit its clinical application. There are several different mechanisms involved in DOX-induced cardiotoxicity. Oxidative stress (OS) is caused by an imbalance between reactive oxygen species (ROS) and endogenous antioxidants in response to injury, which can lead to myocardial toxicity. The aim of this review was to investigate the mechanisms underlying the effects of oxidative stress injury on myocardial toxicity, from three different aspects: the increase in downstream oxidative stress products, the reduction in upstream antioxidative stress products, and subcellular organelles. Finally, there are some anti-oxidative drugs that show efficacy in limiting DOX-induced cardiotoxicity. It is necessary to fully understand the toxicity of DOX to the myocardium and achieve symptomatic treatment.

Citations

Nov 16, 2019·European Journal of Haematology·Jung-Suk Choi, Anthony Berdis
Mar 11, 2020·Antioxidants & Redox Signaling·Christian Cadeddu DessalviGiuseppe Mercuro
Oct 21, 2019·Basic & Clinical Pharmacology & Toxicology·Saeed Nazari Soltan AhmadMehran Mesgari-Abbasi
Jun 12, 2020·Chemical Communications : Chem Comm·Huawei NiuYufen Zhao
Apr 16, 2020·International Journal of Molecular Sciences·Arnab Ghosh, Natalia Shcherbik
Jun 17, 2020·Frontiers in Pharmacology·Yili ZhangYong Wang
Aug 8, 2020·Frontiers in Physiology·Carolina Victoria Cruz JunhoMarcela Sorelli Carneiro-Ramos
Oct 7, 2020·The FEBS Journal·Sabina Y van der ZandenJacques Neefjes
Jan 3, 2021·Cardiovascular Toxicology·Larissa Andrade de Sá FeitosaAndré Sales Barreto
Jan 14, 2021·Cellular and Molecular Life Sciences : CMLS·Jie Wang AJunlian Gu
Dec 16, 2019·Biochemical and Biophysical Research Communications·Xiaoxue YuTao Shen
Dec 23, 2020·Antioxidants·Wenjun Wang, Peter M Kang
Jan 12, 2021·Biochemical Pharmacology·Alison CheongSuzanne M Cutts
Feb 9, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Qijing WuKun Gao
Feb 6, 2021·Oxidative Medicine and Cellular Longevity·Wen-Bin ZhangYao-Gui Wu
Jan 27, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Irene Bissoli, Claudio Muscari
Mar 16, 2021·Journal of Ethnopharmacology·Xiaofen LiWenjun Zou
Apr 10, 2021·Molecular and Cellular Biochemistry·Sonu S VargheseDavinder S Jassal
Apr 23, 2021·Human & Experimental Toxicology·Ava Soltani HekmatKazem Javanmardi
Apr 27, 2021·Metabolism: Clinical and Experimental·Yimin ShenHong Ma
May 1, 2021·International Journal of Molecular Sciences·Mohammad Bani IsmailVishnu Priya Veeraraghavan
May 14, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Defu ZhiRyan F Donnelly
May 11, 2021·Frontiers in Physiology·Nevena DraginicIsidora Milosavljevic
May 29, 2021·Clinical Science·Anna NarezkinaAlice E Zemljic-Harpf
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rossella BasilottaMichela Campolo
Jun 26, 2021·Current Problems in Cardiology·Ashot AvagimyanNizal Sarrafzadegan
Jul 7, 2021·International Journal of Biological Macromolecules·Miaotian XieYicun Chen
Jul 30, 2021·Environmental Science and Pollution Research International·Sara Asaad Abdulkareem AljumailyEyup Altinoz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiotoxicity

Cardiotoxicity refers to the muscle damage or dysfunction of heart electrophysiology caused by drug intake or due to disease complications. It is a well-known side effect of several cytotoxic drugs, especially of the anthracyclines and can lead to long term morbidity. Here is the latest research.

Related Papers

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Osama M AshourAhmed M Mohamadin
Journal of the Egyptian National Cancer Institute
Ihab T Abdel-Raheem, Ahmed A Abdel-Ghany
Environmental Toxicology and Pharmacology
Jun FuXuetao Wei
© 2022 Meta ULC. All rights reserved