Oxidative stress is bane in chronic liver diseases: Clinical and experimental perspective

Arab Journal of Gastroenterology : the Official Publication of the Pan-Arab Association of Gastroenterology
Devaraj Ezhilarasan

Abstract

Oxidative stress plays an important role in the pathogenesis of various chronic liver diseases (CLD) and increasing evidence have confirmed the contributory role of oxidative stress in the pathogenesis of drugs and chemical-induced CLD. Chronic liver injury is manifested as necrosis, cholestasis, fibrosis, and cirrhosis. Chronic administration of anti-tubercular, anti-retroviral, immunosuppressive drugs is reported to induce free radical generation during their biotransformation in the liver. Further, these reactive intermediates are said to induce profibrogenic cytokines, several inflammatory markers, collagen synthesis during the progression of hepatic fibrosis. Oxidative stress and free radicals are reported to induce activation and proliferation of hepatic stellate cells in the injured liver leading to the progression of CLD. Hence, to counteract or to scavenge these reactive intermediates, several plant-derived antioxidant principles have been effectively employed against oxidative stress and came out with promising results in human and experimental models of CLD. This review summarizes the relationships between oxidative stress and different liver pathogenesis induced by drugs and xenobiotics, focusing upon different chro...Continue Reading

Citations

Oct 18, 2018·Journal of Pineal Research·Jose A BogaAna Coto-Montes
Feb 19, 2020·Phytotherapy Research : PTR·Kobra ShiraniGholamreza Karimi
Oct 22, 2019·Drug and Chemical Toxicology·Devaraj Ezhilarasan
Aug 15, 2020·Experimental Biology and Medicine·Devaraj Ezhilarasan
Apr 10, 2019·Polymers·Yuan ChenZhanyong Guo
Oct 20, 2019·Nutrients·Rita RezzaniLuigi Fabrizio Rodella
Aug 1, 2020·BioMed Research International·Ye TaoXiance Sun
Feb 25, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Maxime G ZermattenLorenzo Alberio
Jan 14, 2020·Naunyn-Schmiedeberg's Archives of Pharmacology·Ezhilarasan DevarajBrundha Marimuthu Parasuraman
Jan 5, 2021·Journal of Biochemical and Molecular Toxicology·Devaraj Ezhilarasan, Subramanian Raghunandhakumar
Aug 29, 2020·European Journal of Pharmacology·Devaraj Ezhilarasan
May 13, 2021·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Devaraj Ezhilarasan
Nov 14, 2021·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ezhilarasan DevarajNajimi Mustapha

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