Oxidative stress markers and apoptosis in the prostate of diabetic rats and the influence of vitamin C treatment

Journal of Cellular Biochemistry
Marina Guimarães GobboRejane Maira Góes

Abstract

Negative consequences of diabetes on the prostate such as involution are associated with diminished testosterone, insulin deficiency, and hyperglycemia. The contributions of oxidative damage, which usually increases with diabetes, are unknown for these alterations. This study evaluated the impact of streptozotocin-induced diabetes on the biomarkers of the antioxidant system of rat ventral prostate, the influence of vitamin C supplementation on these biomarkers, and on the balance between cell proliferation and death. Diabetes (D) was induced in Wistar male rats by streptozotocin (5 mg/100 g b.w., i.p.). Control animals (C) were injected with a vehicle. Vitamin C (150 mg/kg b.w./day) supplementation was introduced by gavage in diabetes (D + V) as well as control (C + V) groups. Thirty days after diabetes onset, the rats were killed and the ventral prostates were analyzed using light microscopy, immunocytochemistry, and biochemical assays for biomarkers of oxidative stress. In comparison to control groups, the levels of circulating testosterone, proliferating, and androgen receptor-positive cells decreased in diabetic groups regardless of vitamin C treatment whereas apoptosis was increased. The levels of superoxide dismutase and ...Continue Reading

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Citations

Dec 23, 2014·International Journal of Experimental Pathology·Silas Amâncio SilvaDaniele Lisboa Ribeiro
Jun 13, 2015·Oxidative Medicine and Cellular Longevity·Marina G GobboRejane M Góes
Apr 24, 2014·Journal of Basic and Clinical Physiology and Pharmacology·Atish PrakashAnil Kumar

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis