Oxidative stress markers are elevated in exhaled breath condensate of workers exposed to nanoparticles during iron oxide pigment production

Journal of Breath Research
Daniela PelclováSergey Zakharov

Abstract

Markers of oxidative stress and inflammation were analysed in the exhaled breath condensate (EBC) and urine samples of 14 workers (mean age 43  ±  7 years) exposed to iron oxide aerosol for an average of 10  ±  4 years and 14 controls (mean age 39  ±  4 years) by liquid chromatography-electrospray ionization-mass spectrometry/mass spectrometry (LC-ESI-MS/MS) after solid-phase extraction. Aerosol exposure in the workplace was measured by particle size spectrometers, a scanning mobility particle sizer (SMPS) and an aerodynamic particle sizer (APS), and by aerosol concentration monitors, P-TRAK and DustTRAK DRX. Total aerosol concentrations in workplace locations varied greatly in both time and space. The median mass concentration was 0.083 mg m(-3) (IQR 0.063-0.133 mg m(-3)) and the median particle concentration was 66 800 particles cm(-3) (IQR 16 900-86 900 particles cm(-3)). In addition, more than 80% of particles were smaller than 100 nm in diameter. Markers of oxidative stress, malondialdehyde (MDA), 4-hydroxy-trans-hexenale (HHE), 4-hydroxy-trans-nonenale (HNE), 8-isoProstaglandin F2α (8-isoprostane) and aldehydes C6-C12, in addition to markers of nucleic acid oxidation, including 8-hydroxy-2-deoxyguanosine (8-OHdG), 8-hydro...Continue Reading

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Citations

Apr 28, 2017·The European Respiratory Journal·Ildiko HorváthTeunis J Vink
Feb 29, 2020·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Jody MorganAlison L Jones
Apr 10, 2019·Journal of Breath Research·Edoardo GaudeMarc P van der Schee
Jun 13, 2018·Journal of Breath Research·Pawel MochalskiHossam Haick
Sep 14, 2017·Journal of Breath Research·Martin T GauggPablo Martinez-Lozano Sinues
Jul 10, 2019·Journal of Breath Research·Annalisa CampanellaStefania Tommasi
Jul 10, 2019·Journal of Breath Research·Joachim D Pleil, Antony Williams
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