Oxidative stress markers at birth: Analyses of a neonatal population

Acta histochemica
Mario GiuffrèGiovanni Li Volti

Abstract

In order to further understand neonatal stress and, thus, control it efficaciously, there is a need for more information on the manifestations of stress at the molecular level in the newborn, with particular regard to oxidants, and anti-oxidant and anti-stress mechanisms, including mitochondrial heat shock protein-chaperones such as Hsp60. We investigated patterns of anti-oxidants, biomarkers of oxidative stress, and Hsp60 levels in sera from newborns and found significant associations between glutathione (GSH) levels and gestational age, delivery modality, and lipid hydroperoxydes (LOOH) level. LOOH levels and spontaneous (vaginal) delivery were independently associated with increased GSH levels when these were above the median. Hsp60 and LOOH levels were positively correlated whereas Hsp60 and GSH levels were inversely correlated in spontaneously delivered newborns; in contrast, Hsp60 and GSH levels were positively correlated in newborns delivered by cesarea. Our results point to new directions in the search for definite patterns of GSH, LOOH, and Hsp60 in the newborn's serum that might have functional and diagnostic significance and that could help in the monitoring of newborn health during and after delivery. In addition, t...Continue Reading

References

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Oct 4, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Mario GiuffrèGiovanni Corsello
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Mar 4, 2014·Critical Reviews in Food Science and Nutrition·Giuseppina MarrazzoGiovanni Li Volti

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Citations

Apr 22, 2015·Acta histochemica·Gaetano MagroRosalba Parenti
Jul 13, 2016·Oxidative Medicine and Cellular Longevity·Yasemin Ozsurekci, Kubra Aykac
Oct 18, 2016·Clinical Biochemistry·Chike Bellarmine ItemVassiliki Konstantopoulou
Dec 18, 2018·Frontiers in Pediatrics·Isabella PanfoliLuca A Ramenghi
Mar 9, 2021·Frontiers in Pediatrics·Giuliana FerranteMario Giuffrè

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