Oxidative stress-mediated antiproliferative effects of furan-containing sulfur flavors in human leukemia Jurkat cells

Food Chemistry
Gongliang ZhangHong-Man Hou

Abstract

Antiproliferative effects of 15 sulfides were investigated in human leukemia Jurkat cells. Treatment with 5-50 μM of nine monosulfides and two linear disulfides did not induce DNA fragmentation. Whereas, furan-containing sulfur flavors including methyl 2-methyl-3-furyl disulfide (MMFDS), bis (2-methyl-3-furyl) disulfide (BMFDS), methyl furfuryl disulfide (MFDS) and difurfuryl disulfide (DFDS) induced DNA fragmentation to a varying extent in Jurkat cells. The cell viability-reduction effect of these sulfur flavors was in the following order: DFDS>BMFDS>MMFDS>MFDS based on the IC50 values. MMFDS and BMFDS, but not DFDS, significantly increased the intracellular ROS level by 1.90- and 3.02-fold, respectively. Addition of N-acetylcysteine (NAC) or glutathione (GSH) partially suppressed induction of DNA fragmentation, apoptosis and caspase-3 activation by MMFDS and BMFDS. These results suggest that the furan-containing disulfides have a strong antiproliferative effect, and the oxidative stress and subsequent caspase-3 activation are involved in antiproliferative effect induced by MMFDS and BMFDS in Jurkat cells.

References

Jan 1, 1994·Immunology Today·T M Buttke, P A Sandstrom
Jan 1, 1996·Medicinal Research Reviews·K C Agarwal
Mar 14, 1997·The Journal of Biological Chemistry·A J Polverino, S D Patterson
Feb 24, 2001·Drug Metabolism and Drug Interactions·A M Le Bon, M H Siess
Feb 7, 2003·Current Cancer Drug Targets·Martha Thomson, Muslim Ali
Oct 27, 2004·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·C-C WuL Y Sheen
Sep 20, 2005·Molecular Cancer Therapeutics·Danhua XiaoI Bernard Weinstein
Oct 1, 2005·Bioscience, Biotechnology, and Biochemistry·Shin AritaMikiro Tada
Jun 21, 2007·Journal of Agricultural and Food Chemistry·Pilar Ruiz Perez-CachoRussell Rouseff
Jun 27, 2007·Journal of Pharmaceutical Sciences·Tomris Ozben
Aug 8, 2008·Bioscience, Biotechnology, and Biochemistry·Gongliang ZhangYoshiyuki Murata
Oct 24, 2008·Journal of Agricultural and Food Chemistry·Mizuho Takahashi, Takayuki Shibamoto
Nov 11, 2008·Bioscience, Biotechnology, and Biochemistry·Gongliang ZhangYoshiyuki Murata
Jan 14, 2009·Molecular Cancer Therapeutics·Sarah R McWhinneyHoward L McLeod
Jun 10, 2009·Journal of Medical Genetics·S GhavamiM Los
May 13, 2010·Journal of Agricultural and Food Chemistry·Hsiao Chi WangLee-Yan Sheen
Aug 18, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yuping LiuBaoguo Sun
Aug 19, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Manabu MinamiHisanori Horiuchi
Nov 6, 2012·Food Chemistry·Paramasivan PoornimaViswandha Vijaya Padma
Jan 22, 2013·Journal of Agricultural and Food Chemistry·Roman KubecNicolás García
Jul 3, 2013·The Journal of Physical Chemistry. a·Halima MouhibWolfgang Stahl

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Citations

Jan 19, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Gong-Liang ZhangHong-Man Hou
Feb 16, 2016·Korean Journal for Food Science of Animal Resources·FengQi YangChi-Ho Lee
Nov 4, 2020·Journal of Agricultural and Food Chemistry·Jinxin XieRi-Yuan Tang
Nov 9, 2021·Metabolic Brain Disease·Larissa Menezes da SilveiraMayara Sandrielly Pereira Soares

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