Oxidative stress on mitochondrial antioxidant defense system in the aging process: role of DL-alpha-lipoic acid and L-carnitine

Clinica Chimica Acta; International Journal of Clinical Chemistry
S SavithaChinnakannu Panneerselvam

Abstract

Oxidative damage is hypothesized to accumulate throughout the lifetime of an organism, eventually giving rise to aging. The mitochondria may be the primary cellular source and target of endogenous ROS as they are produced as a normal byproduct of the electron transport system. Male albino Wistar rats were used in this study. The animals were divided into 6 groups, each group consisting of 6 animals. Groups I, III, and V were young, middle-aged and aged control rats and Groups II, IV, and VI were treated with carnitine (300 mg/kg bw) and dl-alpha-lipoic acid (150 mg/kg bw), respectively. After the treatment period, the animals were sacrificed and the heart and skeletal muscle were removed for analysis. There was a significant reduction in the levels of antioxidants in both middle-aged and aged rats whereas the thiobarbituric acid reactive substances were found to be increased. Co-supplementation of carnitine and lipoic acid improved the antioxidant status and brought down the levels of TBARS. Co-supplementation of lipoic acid with carnitine has a beneficial effect in reversing the age-related abnormalities seen in aging. This effect was associated with the decrease in free radical production and rise in antioxidant levels by car...Continue Reading

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Dec 1, 1991·The American Journal of Clinical Nutrition·C J Rebouche
Apr 1, 1991·Mechanisms of Ageing and Development·I SemseiA Richardson
Jan 1, 1990·Free Radical Biology & Medicine·B Bandy, A J Davison
Jan 1, 1988·Annual Review of Biochemistry·L L Bieber
Feb 9, 1973·Science·J T RotruckW G Hoekstra
Sep 1, 1967·Brain : a Journal of Neurology·G K van WijngaardenC A Feltkamp
Feb 1, 1984·Biochemical Pharmacology·M Ogata, H Aikoh
Jan 1, 1984·Methods in Enzymology·I D Desai
Aug 1, 1995·Free Radical Biology & Medicine·L PackerH J Tritschler
Nov 1, 1994·Free Radical Biology & Medicine·J J Chen, B P Yu
Jun 30, 1994·Annals of the New York Academy of Sciences·D Harman
Nov 24, 1993·Biochimica Et Biophysica Acta·E AlvarezA Machado
Jan 1, 1994·Physiological Reviews·B P Yu
May 1, 1993·Experimental Gerontology·M TakasawaT Ozawa
Sep 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·B N AmesT M Hagen
Jan 1, 1997·Free Radical Biology & Medicine·L PackerK Wessel
Sep 1, 1997·General Pharmacology·G P BiewengaA Bast
Aug 5, 1998·Proceedings of the National Academy of Sciences of the United States of America·T M HagenB N Ames
Sep 16, 1998·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J LykkesfeldtB N Ames
Dec 17, 1998·Scandinavian Journal of Rheumatology·A KiziltuncL Cerrahoğlu
Feb 17, 2000·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·P ArivazhaganC Panneerselvam
Jun 23, 2001·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·M M Sayed-AhmedM Calvani
Oct 24, 2001·Experimental Gerontology·P J Arockia Rani, C Panneerselvam
May 22, 2003·Drugs in R&D·Sundaram KumaranChinnakkannu Panneerselvam
Mar 1, 1991·Archives of Gerontology and Geriatrics·A MachadoC Santa Maria

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Citations

Apr 1, 2009·Archivum Immunologiae Et Therapiae Experimentalis·Anna Goraca, Katarzyna Asłanowicz-Antkowiak
May 28, 2005·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·S SavithaC Panneerselvam
Jan 30, 2009·Cardiovascular Research·Kerstin BoenglerGerd Heusch
Jul 28, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Savitha Sethumadhavan, Panneerselvam Chinnakannu
Oct 25, 2008·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Arnaud BernardJean Demarquoy
Jan 25, 2012·International Journal of Molecular Sciences·Peng ChenYong-Ze Jie
Nov 17, 2009·Journal of Cancer Research and Clinical Oncology·Panneerselvam JananiChandrakesan Parthasarathy
Apr 24, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·N P SudheeshC V Krishnan
Jan 2, 2010·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·N P SudheeshK K Janardhanan
Dec 15, 2007·Experimental Gerontology·Vadivel Senthil KumaranPeriandavan Kalaiselvi
Feb 13, 2009·British Journal of Pharmacology·Csaba Szabo
Mar 5, 2011·Basic & Clinical Pharmacology & Toxicology·Luis A Méndez-CuestaAbel Santamaría
Sep 5, 2012·The Journal of Pharmacy and Pharmacology·Jayasudha ElavarasanKalaiselvi Periandavan
Apr 29, 2006·Chemico-biological Interactions·Gopalakrishnan RamakrishnanThiruvengadam Devaki
Nov 18, 2006·Biochimica Et Biophysica Acta·Caroline RigaultJean Demarquoy
May 24, 2016·Scientific Reports·Ana P M TavaresM Goreti F Sales
Aug 19, 2007·Journal of Cardiovascular Pharmacology·Augusto OrlandiLuigi Giusto Spagnoli
Jun 28, 2006·Biogerontology·Savitha Sethumadhavan, Panneerselvam Chinnakannu
Oct 12, 2007·Experimental Dermatology·Kerstin FoitzikRalf Paus
Oct 23, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mark L HudesBruce N Ames
Sep 15, 2011·Asian Pacific Journal of Tropical Medicine·Subramaniam RamachandranK T Manisenthil Kumar
Jul 31, 2018·Genome Biology·Fernando A SeixasJosé Melo-Ferreira
Jul 9, 2020·Nutrients·Alina KepkaNapoleon Waszkiewicz

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