Oxidative Stress Related to Iron Metabolism in Relapsing Remitting Multiple Sclerosis Patients With Low Disability

Frontiers in Neuroscience
Mariacristina SiottoFabrizio Vernieri

Abstract

Oxidative status may play a role in chronic inflammation and neurodegeneration which are considered critical etiopathogenetic factors in Multiple Sclerosis (MS), both in the early phase of the disease and in the progressive one. The aim of this study is to explore oxidative status related to iron metabolism in peripheral blood of stable Relapsing-Remitting MS with low disability. We studied 60 Relapsing-Remitting MS patients (age 37.2 ± 9.06, EDSS median 1.0), and 40 healthy controls (age 40.3 ± 10.86). We measured total hydroperoxides (dROMs test) and Total Antioxidant Status (TAS), along with the iron metabolism biomarkers: Iron (Fe), ferritin (Ferr), transferrin (Tf), transferrin saturation (Tfsat), and ceruloplasmin (Cp) panel biomarkers [concentration (iCp) and enzymatic activity (eCp), copper (Cu), ceruloplasmin specific activity (eCp:iCp), copper to ceruloplasmin ratio (Cu:Cp), non-ceruloplasmin copper (nCp-Cu)]. We computed also the Cp:Tf ratio as an index of oxidative stress related to iron metabolism. We found lower TAS levels in MS patients than in healthy controls (CTRL) and normal reference level and higher dROMs and Cp:Tf ratio in MS than in healthy controls. Cp and Cu were higher in MS while biomarkers of iron me...Continue Reading

References

Oct 31, 1989·Clinica Chimica Acta; International Journal of Clinical Chemistry·T Makino
Jan 1, 1982·Critical Reviews in Clinical Laboratory Sciences·P L Wolf
Jan 1, 1994·Methods in Enzymology·C Rice-Evans, N J Miller
Aug 27, 1999·Journal of Neurology·E KargL Vécsei
Jun 11, 2002·Annual Review of Nutrition·Nathan E Hellman, Jonathan D Gitlin
Mar 29, 2003·Annals of Clinical Biochemistry·J M Walshe, UNKNOWN Clinical Investigations Standing Committee of the Association of Clinical Biochemists
Dec 3, 2005·Multiple Sclerosis : Clinical and Laboratory Research·G FerrettiL Provinciali
Oct 13, 2006·Chest·Mehmet Ibrahim HarmaOzcan Erel
Dec 13, 2006·Pulmonary Pharmacology & Therapeutics·Zoe D DaniilKonstantinos I Gourgoulianis
Apr 5, 2007·Journal of Clinical Pathology·Patrick J TwomeyAnthony S Wierzbicki
Apr 14, 2007·Current Medicinal Chemistry·T Carbonell, R Rama
Mar 15, 2008·The Canadian Journal of Cardiology·Ayşe Yeşim GöçmenSaadet Gümuşlü
Dec 9, 2008·Journal of Neurology, Neurosurgery, and Psychiatry·P ZamboniF Salvi
Feb 21, 2009·Stroke; a Journal of Cerebral Circulation·Claudia AltamuraFabrizio Vernieri
Sep 3, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Ajay Vikram Singh, Paolo Zamboni
Nov 21, 2009·Cell Death and Differentiation·D CentonzeG Martino
Jan 15, 2011·International Journal of Alzheimer's Disease·Rosanna SquittiPaolo M Rossini
Mar 10, 2011·Annals of Neurology·Chris H PolmanJerry S Wolinsky
Oct 25, 2011·Clinical Biochemistry·Elżbieta MillerIreneusz Majsterek
Nov 15, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·W H Wilson TangStanley L Hazen
Feb 15, 2012·Clinical Biochemistry·Inmaculada TassetIsaac Túnez
Jun 21, 2012·Nature Reviews. Neuroscience·Peter K StysJeroen J G Geurts
Aug 14, 2012·Journal of the Neurological Sciences·Sayonara Rangel OliveiraEdna Maria Vissoci Reiche
Jul 1, 2010·Indian Journal of Medical Sciences·Ajay Vikram Singh
Nov 17, 2012·Journal of Pediatric Gastroenterology and Nutrition·Valerio NobiliRosanna Squitti
Nov 29, 2012·Journal of Neurosciences in Rural Practice·Ajay Vikram SinghPaolo Zamboni
Feb 22, 2013·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Isao TaguchiTeruo Inoue
Apr 3, 2013·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Ulrike Träger, Sarah J Tabrizi
Sep 28, 2013·Journal of Alzheimer's Disease : JAD·Rosanna SquittiAshley I Bush
Nov 1, 2013·Clinical & Developmental Immunology·Genaro G OrtizErandis D Torres-Sánchez
Jan 6, 2016·Free Radical Research·Francesco ColombiniAngelo Alberti
Feb 3, 2016·Journal of Alzheimer's Disease : JAD·Mariacristina SiottoRosanna Squitti
Nov 11, 2016·Oxidative Medicine and Cellular Longevity·Bożena Adamczyk, Monika Adamczyk-Sowa

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Citations

Mar 8, 2020·Antioxidants & Redox Signaling·Carlo CervellatiGiuseppe Valacchi
Aug 23, 2020·International Journal of Molecular Sciences·Maryam GulAmmar Chaudhry
Sep 26, 2020·Journal of Magnetic Resonance Imaging : JMRI·Haiqi YeKejia Cai
Nov 7, 2019·Journal of Clinical Medicine·Rodica PadureanuAna-Maria Buga
Oct 18, 2019·Journal of Neural Transmission·Thomas MüllerKatja Frommholz
Aug 9, 2020·Journal of Molecular Neuroscience : MN·Tobore Onojighofia Tobore
Nov 27, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Dragana ObradovicJelena Kotur-Stevuljevic
Dec 4, 2020·International Journal of Molecular Sciences·Jean-Philippe Dales, Sophie Desplat-Jégo
Feb 22, 2021·Biological Trace Element Research·Elahe NirooeiHamed Akbari
Aug 7, 2021·Biomolecules·Thomas MüllerKatja Frommholz

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Methods Mentioned

BETA
Electron Paramagnetic Resonance
venous
percutaneous transluminal angioplasty

Software Mentioned

Futura
SPSS Statistics

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