Oxidative stress response in patients infected by diverse hepatitis C virus genotypes

Hepatitis Monthly
Mohammad Hassan Khadem AnsariFatemeh Kheradmand

Abstract

The molecular mechanism of hepatitis C-virus (HCV) genome-specific pathogenesis remains unclear. Oxidative stress is an important pathophysiological mechanism in chronic HCV infection, but its relation to HCV genotypes has not been thoroughly examined. In the present case-control study, the effect of diverse HCV genotypes on oxidative status changes was investigated. From 310 patients examined by enzyme immunoassay and PCR, 160 patients with positive results for HCV with previously determined genotypes were chosen. For the control group, 160 first time blood donors referred to the Regional Blood Transfusion organization of the West Azerbaijan province, northwestern Iran were selected. Oxidative stress markers such as total antioxidant status (TAS), serum levels of reduced (GSH) and oxidized (GSSG) glutathione, Gamma-glutamyl transferase (GGT) and malondialdehyde (MDA) were evaluated in patients infected with diverse HCV genotypes and those in the control group. In the patient and control groups, the mean ± SE of TAS, GSH, GSSG, GGT and MDA were 1.04 ± 0.35 vs. 2.68 ± 0.77, 1.25 ± 0.37 vs. 3.12 ± 0.58, 0.20 ± 0.05 vs. 0.08 ± 0.04, 26.82 ± 5.62 vs 8.28 ± 2.03 and 2.56 ± 0.60 vs. 0.93 ± 0.34. All markers had statistical difference...Continue Reading

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Citations

Dec 24, 2015·International Journal of Molecular Sciences·Kívia Queiroz de AndradeMarília Oliveira Fonseca Goulart
Nov 6, 2015·Mediators of Inflammation·Mads Emil Bjørn, Hans Carl Hasselbalch
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Mar 7, 2021·Antioxidants·Mariapia VairettiClarissa Berardo
Mar 13, 2021·Oxidative Medicine and Cellular Longevity·Vukica ĐorđevićJana Pešić Stanković

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Methods Mentioned

BETA
genotyping
PCR
Assay
MDA

Software Mentioned

SPSS

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