Oxidative stress status in kidney tissue after losartan and atenolol treatment in experimental renal failure

Nephron. Experimental Nephrology
Ulle PechterMai Ots

Abstract

Rats with subtotal nephrectomy (5/6NPX) rapidly develop systemic hypertension and proteinuria. The aim of our study was to evaluate the changes in oxidative stress parameters after 2 and 4 weeks of treatment with renin-angiotensin system (RAS)-blocking agent losartan and beta-blocking agent atenolol in experimental chronic renal failure (CRF). After 5/6NPX, rats were immediately treated with losartan or atenolol. The lipid peroxidation (LPO) products malondialdehyde and 4-hydroxyalkenals and oxidized and reduced glutathione values were measured in the renal cortex tissue and in blood; isoprostanes in urine. There were no differences in the blood pressure values, serum creatinine levels or in daily proteinuria using both antihypertensive treatments. Losartan treatment lowered significantly LPO in kidney tissue after 2 and 4 weeks of treatment compared with untreated and atenolol-treated animals and induced the decrease of excretion of isoprostanes in urine at the end of the study. There was no ameliorating impact of losartan or atenolol observed in the blood status of oxidative stress in this period of time. In the early period of experimental CRF, losartan treatment but not atenolol treatment induces significant decline in LPO ...Continue Reading

Citations

Jul 28, 2015·Journal of Molecular and Cellular Cardiology·Nikunj R Shah, Michael Mahmoudi
Feb 3, 2007·Kidney & Blood Pressure Research·Barry B McGuireNeil G Docherty
Aug 10, 2006·American Journal of Physiology. Renal Physiology·Clarice K FujiharaRoberto Zatz

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