Oxidative stress to dopaminergic neurons as models of Parkinson's disease

Annals of the New York Academy of Sciences
G GilleW-D Rausch

Abstract

The effects of exogenous toxins (MPP(+), rotenone) and potentially neurotoxic properties of levodopa (L-DOPA) on the survival rate of dopaminergic neurons in dissociated primary culture are presented. Dopamine agonists show a capacity to counteract MPP(+)-toxicity. Moreover, a preserving potential of the antioxidant and bioenergetic coenzyme Q(10) (CoQ(10)) on the activities of tyrosine hydroxylase (TH), complexes I and II of the respiratory chain, and hexokinase activity in striatal slice cultures against MPP(+) is demonstrated.

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Citations

Jun 11, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Angela De IuliisPaola Arslan
Feb 11, 2009·The Journal of Biological Chemistry·Christine L KraghPoul Henning Jensen
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Sep 13, 2011·Hormones and Behavior·Rebecca L CunninghamAndrea Giuffrida
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May 9, 2015·Expert Review of Neurotherapeutics·Gulam MustafaJaved Ali
Apr 4, 2021·Antioxidants·Ana Patricia Duarte-JuradoHumberto Rodriguez-Rocha

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