Oxidative variables in the rat brain after sepsis induced by cecal ligation and perforation

Critical Care Medicine
T BarichelloFelipe Dal-Pizzol

Abstract

The underlying mechanisms of the changes in mental status, septic encephalopathy, and long-term cognitive symptoms in sepsis survivors have only been defined in part. The present study was undertaken to assess different variables of oxidative stress in several brain structures after cecal ligation and perforation in the rat. Prospective animal study. Animal basic science laboratory. Male Wistar rats, weighing 250-350 g. Rats were subjected to cecal ligation and perforation (sepsis group) with saline resuscitation (at 50 mL/kg immediately and 12 hrs after cecal ligation and perforation) or sham operation (control group). Oxidative damage, assessed by the thiobarbituric acid reactive species and the protein carbonyl assays, occurred early (after 6 hrs) in the course of sepsis development in the hippocampus, cerebellum, and cortex. At longer times after sepsis induction (12-96 hrs), there was no evidence of oxidative damage in all analyzed structures. Except for the striatum, earlier in sepsis development (6 hrs) we demonstrated an increase in superoxide dismutase activity without a proportional increase in catalase activity with a consequent increase in the relation of superoxide dismutase/catalase. The balance between these enzy...Continue Reading

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Citations

Jun 11, 2008·Intensive Care Medicine·Lisiane TuonFelipe Dal-Pizzol
Oct 12, 2012·Molecular Neurobiology·Clarissa M ComimStephen L Leib
Jun 24, 2011·Journal of Physiology and Biochemistry·Masoud AlirezaeiSaeed Nazifi
Aug 23, 2007·Antioxidants & Redox Signaling·Shyam Biswal, Daniel G Remick
Jan 26, 2013·Epidemiologic Reviews·Francis Mawanda, Robert Wallace
Sep 15, 2007·Critical Care Medicine·Tatiana BarichelloFelipe Dal-Pizzol
Aug 24, 2007·Critical Care Medicine·Ramona O Hopkins
May 23, 2008·Critical Care Medicine·Joana da Costa P d'AvilaFernando A Bozza
Feb 6, 2010·Critical Care Medicine·Emanuele IacoboneTarek Sharshar
May 31, 2013·Annals of Intensive Care·Romain SonnevilleTarek Sharshar
May 27, 2011·Critical Care : the Official Journal of the Critical Care Forum·Andrea PolitoTarek Sharshar
Nov 23, 2006·Critical Care : the Official Journal of the Critical Care Forum·Eric B Milbrandt, Derek C Angus
Jan 10, 2013·PLoS Pathogens·Patricia A ReisHugo C Castro-Faria-Neto
Feb 28, 2014·Journal of Neuroinflammation·Marina S HernandesFernando A Bozza
Nov 16, 2013·Molecular Neurobiology·Francielle MinaFelipe Dal-Pizzol
Apr 6, 2013·International Immunopharmacology·YueYu HuBaoRong Zhang
Oct 1, 2010·Inflammation·Ricardo Obalski de MelloJarbas Rodrigues de Oliveira
May 16, 2014·Neurotoxicity Research·Fernanda SilvestreFabricia Petronilho
Aug 15, 2009·Neurochemical Research·Felipe Dal-PizzolEmilio L Streck
Feb 16, 2013·Expert Review of Anti-infective Therapy·Nicolas AdamTarek Sharshar
Oct 4, 2015·Inflammation·Fabricia PetronilhoFrancieli Vuolo
Aug 23, 2011·Pathology, Research and Practice·Carlos A PrauchnerJoão B T da Rocha
Oct 6, 2010·International Journal of Biological Macromolecules·Daye ChengMinglin Jin
Jul 7, 2009·Journal of Critical Care·Jorge I F SalluhUNKNOWN Brazilian Research in Intensive Care Network
Apr 18, 2008·Mitochondrion·Paula H ZapeliniFelipe Dal-Pizzol
Feb 5, 2008·Critical Care Clinics·Shidasp SiamiTarek Sharshar
Jan 1, 2008·The Journal of Surgical Research·Stefan HoferMarkus A Weigand
Jun 7, 2013·Synapse·Amanda V SteckertFelipe Dal-Pizzol
Jun 5, 2014·Synapse·Andriele VieiraFabricia Petronilho
Aug 2, 2011·Brain Research·Sezen Milli AvtanBulent Ahishali
Oct 13, 2014·Environmental Toxicology and Pharmacology·Merve BacanlıNurşen Başaran
Apr 14, 2012·Brain, Behavior, and Immunity·Fabricia PetronilhoFelipe Dal-Pizzol

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