Oxidatively damaged DNA in the nasal epithelium of workers occupationally exposed to silica dust in Tuscany region, Italy

Mutagenesis
Marco PelusoFabio Capacci

Abstract

Chronic silica exposure has been associated to cancer and silicosis. Furthermore, the induction of oxidative stress and the generation of reactive oxygen species have been indicated to play a main role in the carcinogenicity of respirable silica. Therefore, we conducted a cross-sectional study to evaluate the prevalence of 3-(2-deoxy-β-D-erythro-pentafuranosyl)pyrimido[1,2-α]purin-10(3H)-one deoxyguanosine (M1dG) adducts, a biomarker of oxidative stress and peroxidation of lipids, in the nasal epithelium of 135 silica-exposed workers, employed in pottery, ceramic and marble manufacturing plants as well as in a stone quarry, in respect to 118 controls living in Tuscany region, Italy. The M1dG generation was measured by the (32)P-postlabelling assay. Significant higher levels of M1dG adducts per 10(8) normal nucleotides were observed in the nasal epithelium of smokers, 77.9±9.8 (SE), and in those of former smokers, 80.7±9.7 (SE), as compared to non-smokers, 57.1±6.2 (SE), P = 0.001 and P = 0.004, respectively. Significant increments of M1dG adducts were found in the nasal epithelium of workers that handle artificial marble conglomerates, 184±36.4 (SE), and in those of quarry workers, 120±34.7 (SE), with respect to controls, 50.6±...Continue Reading

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Citations

Jun 5, 2016·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·Beniamino BrancatoMarco E M Peluso
Oct 25, 2016·Laboratory Investigation; a Journal of Technical Methods and Pathology·Jingjin YangChunhui Ni
Nov 23, 2017·Journal of Toxicology and Environmental Health. Part a·Christina UmbrightPius Joseph
Oct 10, 2019·Journal of Toxicology and Environmental Health. Part a·Georg WultschSiegfried Knasmüller
Dec 14, 2019·Reviews in Medical Virology·Ali Mahmoud AhmedNguyen Tien Huy
Feb 26, 2016·Toxicology Research·Roberto BonoMarco E M Peluso
Oct 11, 2017·Mutagenesis·Hatice Gul AnlarNursen Basaran
Feb 29, 2020·Molecular and Cellular Biochemistry·Neslihan AksuSuna Sabuncuoğlu
Apr 3, 2019·Environmental Research·Roberto BonoMarco Peluso
Jun 5, 2021·Mutation Research. Reviews in Mutation Research·Georg WultschSiegfried Knasmüller
Jun 16, 2021·Journal of Applied Toxicology : JAT·Caroline Portela PeruzziSolange Cristina Garcia

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