Oxidised mannan antigen conjugates preferentially stimulate T1 type immune responses

Veterinary Immunology and Immunopathology
I F McKenzieGeoffrey A Pietersz

Abstract

It is desirable to be able to produce either T1 or T2 responses and we have found that, in mice, mannose--coupled antigens stimulated T2 type responses antibodies and CTLs, whereas if oxidized, mannose--coupled antigens stimulated T1 responses little antibody and a potent CTL response. In addition, the cytokine profiles support the T1rT2 differentiation with these immunizations, in that oxidized mannan antigen gives IFNg, IL-2 and IL-12 production, whereas in the absence of oxidization, IL-4 and not the other cytokines is produced. A number of antigens have been examined--particularly Mucin 1 and the delivery method using mannose may be applicable to the other antigens.

References

Sep 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D L BarndO J Finn
Oct 24, 1995·Proceedings of the National Academy of Sciences of the United States of America·V ApostolopoulosI F McKenzie
Aug 12, 1993·Annals of the New York Academy of Sciences·J Taylor-PapadimitriouP Beverley
Jun 1, 1996·Vaccine·V ApostolopoulosI F McKenzie
Oct 1, 1996·Immunology and Cell Biology·V ApostolopoulosG A Pietersz

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Citations

Nov 23, 2012·Journal of the Royal Society, Interface·Akhilesh Kumar Shakya, Kutty Selva Nandakumar
Jun 17, 2006·Breast Cancer Research : BCR·Vasso ApostolopoulosStamatis Vassilaros
Jul 11, 2006·Immunology·Kuo-Ching ShengVasso Apostolopoulos
Apr 22, 2011·Expert Review of Vaccines·Nikolai Petrovsky, Peter D Cooper
Nov 15, 2013·Journal of Drug Delivery·Vasso ApostolopoulosLily Stojanovska
Sep 5, 2008·Expert Review of Vaccines·Choon-Kit Tang, Vasso Apostolopoulos
Sep 5, 2008·Expert Review of Vaccines·Choon-Kit TangVasso Apostolopoulos
Jun 4, 2010·Expert Review of Vaccines·Magdalena PlebanskiVasso Apostolopoulos
Jan 19, 2007·Molecular Pharmaceutics·Owen ProudfootGeoffrey A Pietersz

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