Oxidized high-density lipoprotein enhances inflammatory activity in rat mesangial cells

Diabetes/metabolism Research and Reviews
Miao ZhangChanglin Mei

Abstract

Inflammation is a mechanism of glomerular damage in chronic glomerulopathies, in which dyslipidaemia plays an important role. Unlike native high-density lipoprotein (HDL), oxidized HDL is thought to be an adverse factor in chronic ischaemic disease and may increase the production of inflammatory cytokines in atheromatous plaques and plasma, but the effect of oxidized HDL on mesangial cells remains unclear. Intracellular reactive oxygen species level was measured. The inflammatory and proapoptotic effects of oxidized HDL were detected in rat mesangial cells by measuring levels of tumour necrosis factor-alpha, regulated upon activation, normal T-cell expressed and secreted, monocyte chemoattractant protein-1, CXC chemokine ligand-1 and early apoptosis. The expression of mitogen-activated protein kinase (MAPK) (p38/MAPK, extracellular-regulated kinase/MAPK and c-Jun N-terminal kinase/MAPK), nuclear factor-kappaB activity and lipoprotein scavenger receptors (CD36, low-density lipoprotein receptor-1 and scavenger receptor BI) were also detected. Oxidized HDL enhanced reactive oxygen species production and upregulated expression of proinflammatory factors, including tumour necrosis factor-alpha, regulated upon activation, normal T-ce...Continue Reading

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Citations

Oct 14, 2011·Cardiovascular Drugs and Therapy·Meiling YanChangping Hu
May 9, 2012·International Journal of Nephrology·Jinhua TangShougang Zhuang
Feb 11, 2015·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Bing LuoGao-Jun Teng
Sep 19, 2017·Nature Reviews. Nephrology·Xiaochun YangXiong Z Ruan
Sep 8, 2017·Frontiers in Physiology·Xinyu YangHongcai Shang
Aug 8, 2021·International Journal of Molecular Sciences·Valentina KonMacRae F Linton

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