PMID: 9544981Apr 17, 1998Paper

Oxidized LDL damages endothelial cell monolayer and promotes thrombocyte adhesion

American Journal of Hematology
B LiuR Dierichs

Abstract

The influence of oxidized low density lipoprotein (LDL) on a human endothelial cell monolayer was examined. The resulting contraction of the oxidized LDL-damaged endothelial cells lets intercellular spaces become enlarged and therefore visible via light microscopy. Electron microscopy reveals that the structural damage facilitates thrombocyte adhesion and formation of microthrombi. Oxidized LDL appears to play a pivotal role in initiating and deteriorating thromboembolic complications.

References

Feb 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·W PalinskiJ L Witztum
Dec 1, 1994·American Heart Journal·C H Hennekens
Dec 1, 1994·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·P Holvoet, D Collen
Aug 1, 1996·American Journal of Hematology·B ZhaoV Gurevich

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Citations

Nov 21, 2000·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·A D Blann
May 21, 2019·Free Radical Research·Pietro ScicchitanoMarco Matteo Ciccone

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