Oxidized low-density-lipoprotein accumulation is associated with liver fibrosis in experimental cholestasis.

Clinics
Güldeniz KaradenizMustafa Cömert

Abstract

The aim of the present study was to examine the probable relationship between the accumulation of oxLDL and hepatic fibrogenesis in cholestatic rats. There is growing evidence to support the current theories on how oxidative stress that results in lipid peroxidation is involved in the pathogenesis of cholestatic liver injury and fibrogenesis. One of the major and early lipid peroxidation products, OxLDL, is thought to play complex roles in various immuno-inflammatory mechanisms. A prolonged (21-day) experimental bile duct ligation was performed on Wistar-albino rats. Biochemical analysis of blood, histopathologic evaluation of liver, measurement of the concentration of malondialdehyde (MDA) and superoxide-dismutase (SOD) in liver tissue homogenates, and immunofluorescent staining for oxLDL in liver tissue was conducted in bile-duct ligated (n=8) and sham-operated rats (n=8). Significantly higher levels of MDA and lower concentrations of SOD were detected in jaundiced rats than in the sham-operated rats. Positive oxLDL staining was also observed in liver tissue sections of jaundiced rats. Histopathological examination demonstrated that neither fibrosis nor other indications of hepatocellular injury were found in the sham-operate...Continue Reading

Citations

Mar 17, 2018·Experimental and Therapeutic Medicine·Shi ChengLing Ma
Jun 9, 2018·The British Journal of Nutrition·Azam EshaghianAli Moradi
Jan 30, 2020·Frontiers in Physiology·Matthew A BurchillBeth A Jirón Tamburini
Mar 13, 2012·Journal of Applied Toxicology : JAT·Mohamed A HammadMohammad K Ashfaq
Apr 16, 2010·Journal of Gastroenterology·Paolo SorrentinoRaffaela Vecchione
Jul 25, 2019·Antioxidants·Laura Inés Elvira-ToralesMaría Jesús Periago-Castón
Jul 14, 2009·Diabetes·Andrea M VincentEva L Feldman
Sep 23, 2020·Cellular and Molecular Gastroenterology and Hepatology·Matthew A BurchillBeth A Jirón Tamburini
Apr 4, 2021·Journal of Gastroenterology and Hepatology·Yang Wang, Yulan Liu
Aug 4, 2011·Clinics and Research in Hepatology and Gastroenterology·Manouchehr NakhjavaniHossein Froutan

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BETA
MDA
biopsy
biopsies

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