Oxidized low-density lipoprotein inhibits endothelium-dependent vasodilation by an antioxidant-sensitive, lysophosphatidylcholine-independent mechanism

Journal of Cardiovascular Pharmacology
Holman ChanUrs P Steinbrecher

Abstract

Previous studies have shown that oxidized low-density lipoprotein (LDL) can impair endothelial function and that this can be overcome in vivo by administration of vitamin E. However, it is unclear whether this effect of oxidized LDL is due to lysophosphatidylcholine or other components of oxidized LDL, and it is also uncertain if the protective effect of vitamin E is related to its antioxidant action. The objectives of the current study were to define how much of the effect of extensively oxidized LDL on endothelium-dependent relaxation (EDR) was in fact due to lysophosphatidylcholine, to determine if the effect of oxidized LDL involved oxidant stress to the endothelium, and, if so, to ascertain if this could be blocked by oxyradical scavengers or antioxidants. Endothelial function was assessed by measuring vasodilation in preconstricted rat mesenteric artery rings in response to acetylcholine. In the presence of 100 microg/mL oxidized LDL, 25-fold higher concentrations of acetylcholine were required for the same degree of vasorelaxation. Similar concentrations of native LDL or acetyl LDL had no effect, but 100 microg/mL phospholipase A(2)-treated LDL or 20 microM lysophosphatidylcholine produced a similar inhibition of EDR. Re...Continue Reading

References

Jan 1, 1992·The Journal of Clinical Investigation·J H ChinB B Hoffman
May 1, 1990·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·M E RosenfeldJ L Witztum
Jan 1, 1991·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·I BjörkhemP Henriksson
Jan 1, 1991·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·J GalleE Bassenge
Feb 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·W PalinskiJ L Witztum
Oct 1, 1989·British Journal of Pharmacology·A DaughertyG Schonfeld
Mar 1, 1987·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·U P SteinbrecherD Steinberg
May 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M T QuinnD Steinberg
Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·T KitaC Kawai
Jun 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·U P SteinbrecherD Steinberg
Oct 1, 1995·Arteriosclerosis, Thrombosis, and Vascular Biology·C SuarnaR Stocker
Jun 1, 1995·The Journal of Clinical Investigation·P HolvoetD Collen
Dec 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·J F KeaneyJ A Vita
Aug 1, 1993·Circulation·S Ballin, C Louis
Oct 1, 1993·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·M OhgushiH Yasue
May 20, 1993·The New England Journal of Medicine·M J StampferW C Willett
May 20, 1993·The New England Journal of Medicine·E B RimmW C Willett
Sep 1, 1995·Journal of Bioluminescence and Chemiluminescence·O CynshiY Fujita

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Citations

Nov 20, 2013·International Journal of Biological Sciences·Peramaiyan RajendranIkuo Nishigaki
Apr 25, 2008·Pathophysiology : the Official Journal of the International Society for Pathophysiology·M KhazaeiI Laher
Aug 12, 2014·BioMed Research International·Tung-Ting ShamShun-Wan Chan
Oct 31, 2012·Journal of Cardiovascular Pharmacology·Nazneen ShaikFlorian Lang
Feb 2, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Katsuyuki NakajimaAkira Tanaka

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