Oxidized phospholipids affect small intestine neuromuscular transmission and serotonergic pathways in juvenile mice.

Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society
Ilaria MarsilioMaria Cecilia Giron

Abstract

Oxidized phospholipid derivatives (OxPAPCs) act as bacterial lipopolysaccharide (LPS)-like damage-associated molecular patterns. OxPAPCs dose-dependently exert pro- or anti-inflammatory effects by interacting with several cellular receptors, mainly Toll-like receptors 2 and 4. It is currently unknown whether OxPAPCs may affect enteric nervous system (ENS) functional and structural integrity. Juvenile (3 weeks old) male C57Bl/6 mice were treated intraperitoneally with OxPAPCs, twice daily for 3 days. Changes in small intestinal contractility were evaluated by isometric neuromuscular responses to receptor and non-receptor-mediated stimuli. Alterations in ENS integrity and serotonergic pathways were assessed by real-time PCR and confocal immunofluorescence microscopy in longitudinal muscle-myenteric plexus whole-mount preparations (LMMPs). Tissue levels of serotonin (5-HT), tryptophan, and kynurenine were measured by HPLC coupled to UV/fluorescent detection. OxPAPC treatment induced enteric gliosis, loss of myenteric plexus neurons, and excitatory hypercontractility, and reduced nitrergic neurotransmission with no changes in nNOS+ neurons. Interestingly, these changes were associated with a higher functional response to 5-HT, alte...Continue Reading

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Citations

Feb 11, 2021·International Journal of Molecular Sciences·Davide BanfiAndreina Baj
Sep 3, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sabah HaqWaliul I Khan

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