Oxidized plasma albumin promotes platelet-endothelial crosstalk and endothelial tissue factor expression

Scientific Reports
Lisa PasterkGunther Marsche

Abstract

Plasma advanced oxidation protein products (AOPPs), a class of pro-inflammatory pathogenic mediators, accumulate in subjects with chronic kidney disease. Whether AOPPs contribute to coagulation abnormalities, which are frequently seen in uremic patients, is unknown. Here we report that AOPPs activate platelets via a CD36-mediated signaling pathway. Activation of signaling pathways by AOPP-platelet interaction resulted in the expression of several platelet activation markers and rapidly induced the expression of CD40 ligand, triggering platelet adhesion to endothelial cells and promoting endothelial tissue factor expression. AOPPs and serum tissue factor levels were considerably increased in end stage renal disease patients on hemodialysis and a significant correlation of AOPPs and serum tissue factor was found. Interestingly, serum levels of AOPPs and tissue factor were substantially lower in stable kidney transplant patients when compared with hemodialysis patients. Given that CD36 is known to transduce the effects of oxidized lipids into platelet hyperactivity, our findings reveal previously unknown pro-thrombotic activities of oxidized plasma albumin via a CD36 dependent pathway.

References

Jan 1, 1977·Transactions - American Society for Artificial Internal Organs·J BemisN Deane
Jan 1, 1993·Nephron·A SagripantiG Barsotti
May 1, 1996·Kidney International·V Witko-SarsatB Descamps-Latscha
Sep 17, 1998·The New England Journal of Medicine·R G Luke
Feb 13, 2001·Kidney International. Supplement·B Descamps-Latscha, V Witko-Sarsat
Oct 16, 2001·Chemical Research in Toxicology·D I Pattison, M J Davies
Mar 21, 2003·The New England Journal of Medicine·Christopher HeeschenUNKNOWN CAPTURE Study Investigators
May 31, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Mark J Sarnak
Aug 12, 2004·Journal of Thrombosis and Haemostasis : JTH·M BonominiV Sirolli
Aug 24, 2004·Current Medicinal Chemistry. Cardiovascular and Hematological Agents·K T TanG Y H Lip
Oct 19, 2004·Seminars in Nephrology·Nosratola D Vaziri
Sep 9, 2005·Frontiers in Bioscience : a Journal and Virtual Library·Arthur J Chu
Dec 8, 2005·JAMA : the Journal of the American Medical Association·Robert M MerionFriedrich K Port
Feb 25, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Shang Xi LiuXun Zhang
Sep 5, 2006·Biochemical and Biophysical Research Communications·Luca MusanteGian Marco Ghiggeri
Jan 5, 2007·Journal of the American Society of Nephrology : JASN·Hong Yan LiDi Xie
Jan 16, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Gunther MarscheErnst Malle
Feb 9, 2007·Journal of the American Society of Nephrology : JASN·Luca MusanteGian Marco Ghiggeri
Aug 28, 2007·Nature Medicine·Eugene A PodrezStanley L Hazen
Dec 25, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Anetta UndasWiesława Tracz
Nov 21, 2008·American Journal of Physiology. Renal Physiology·Xiao Fan WeiMin Liang
Mar 31, 2009·Chemical Research in Toxicology·David I PattisonMichael J Davies
Jul 28, 2009·Journal of Thrombosis and Haemostasis : JTH·M Valiyaveettil, E A Podrez
Nov 13, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Sonia PhiliposeRufina Schuligoi
Nov 13, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Zhenyu LiXiaoping Du
Dec 21, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Fong W LamRolando E Rumbaut
May 4, 2011·Current Opinion in Lipidology·Jerzy-Roch Nofer, Miranda van Eck
Aug 16, 2011·Antioxidants & Redox Signaling·Dalia El-GamalGunther Marsche
May 18, 2012·Kidney International·John T Daugirdas, Angelito A Bernardo
Oct 11, 2012·European Heart Journal·Sumeet SharmaDiana A Gorog
Mar 16, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Veronika BinderGunther Marsche
Jun 25, 2013·Biochimica Et Biophysica Acta·Michael HolzerGunther Marsche
Mar 7, 2014·Antioxidants & Redox Signaling·Donatella PietraforteElisabetta Straface
Jun 19, 2014·Kidney International·Dalia El-GamalGunther Marsche
Dec 3, 2014·Biochimica Et Biophysica Acta·Sanja CurcicGunther Marsche

❮ Previous
Next ❯

Citations

Jun 11, 2020·Journal of the American Society of Nephrology : JASN·Nans FlorensChristophe O Soulage
Nov 19, 2020·Journal of Clinical Medicine·Shungang ZhangSteven T Haller
Apr 4, 2021·Antioxidants·Fuka TabataKazuhiro Miyaji
May 5, 2021·Journal of the American Society of Nephrology : JASN·Constance C F M J BaatenHeidi Noels
Dec 10, 2016·The Journal of Physical Chemistry. B·Alessandra Del GiudiceNicolae V Pavel

❮ Previous
Next ❯

Methods Mentioned

BETA
flow cytometry
chip
ELISA

Software Mentioned

Olympus CellP

Related Concepts

Related Feeds

Blood Coagulation Signaling Pathways

Coagulation is the process by which a blood clot is formed. This process includes both the formation of a platelet plug as well as a cascade of clotting factors resulting in the formation of fibrin strands. Find the latest research on coagulation signaling pathways here.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.