PMID: 6228May 1, 1976

Oxisuran reduction by rabbit tissue preparations

Drug Metabolism and Disposition : the Biological Fate of Chemicals
N R Bachur, R L Felsted

Abstract

Oxisuran, 2-((methylsulfinyl)acetyl)pyridine is reduced to alpha-((methylsulfinyl)methyl-2-pyridinemethanol, oxisuranol, by cytoplasmic enzymes from rabbit liver, kidney, brain, intestine, and lung. The cytoplasmic enzyme from liver is dependent on NADPH as cofactor and has an optimal pH of 6.0. Enzymatic activity is also present in liver mitochondria but at a lower specific activity. The cytoplasmic extracts catalyze the formation of two oxisuranol products, presumably the diastereoisomers described by Di Carlo and associates from in vivo studies. Verification of the product as oxisuranol was accomplished by thin-layer chromatography and mass spectrometry.

Related Concepts

Brain
Protoplasm
Hydrogen-Ion Concentration
Intestines, Small
Kidney
Liver
Lung
Mitochondria, Liver
NADP
Tissue Specificity

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