PMID: 241812Sep 1, 1975Paper

Oxotremorine- and atropine-induced changes of dopamine metabolism in the rat striatum

The Journal of Pharmacy and Pharmacology
F JavoyJ Glowinski


The effects of various doses of oxotremorine and of atropine (30 min, i.p.) on the metabolism of dopamine were examined in the striatum of the rat. Changes in striatal dopamine metabolism were estimated by following either the accumulation of [3H] dopamine 15 min after intravenous injection of [3H] tyrosine or the accumulation of dopa (taken as an index of dopamine synthesis) in animals pretreated with a dopa decarboxylase inhibitor Ro4-4602. Oxotremorine, 0-1 mg kg-1, and atropine, 1 mg kg-1, did not affect dopamine metabolism. Oxotremorine, 0-5 and 1-5 mg kg-1, did not modify dopamine concentrations but increased the accumulation of [3H]dopamine. The drug enhanced dopa formation in animals pretreated with Ro4-4602. Atropine, 5 and 20 mg kg-1, increased the accumulation of [3H]dopamine but did not affect dopamine concentrations. The accumulation of dopa was not modified there being no difference from the saline value in animals pretreated with the dopa decarboxylase inhibitor at high dopamine metabolism and atropine reduced dopamine utilization.


Mar 1, 1974·The Journal of Pharmacy and Pharmacology·F JavoyJ Glowinski
Jun 1, 1971·The Journal of Pharmacy and Pharmacology·N E Andén, P Bédard
Feb 1, 1970·British Journal of Pharmacology·R O'KeeffeM Vogt
Jan 1, 1971·Experientia·G Bartholini, A Pletscher
Dec 1, 1967·Life Sciences·H CorrodiU Ungerstedt


Jun 1, 1988·Biological Psychiatry·S P MahadikS E Karpiak
Oct 21, 1977·Brain Research·M Pérez de la Mora, K Fuxe
Nov 15, 1977·European Journal of Pharmacology·J Z Nowak, A Pilc
Jul 25, 1980·European Journal of Pharmacology·J D DohertyH Y Meltzer
Nov 1, 1981·Pharmacology, Biochemistry, and Behavior·K H Westermann
Jan 1, 1985·General Pharmacology·H De Souza, J Palermo-Neto
Sep 1, 1977·Drug and Alcohol Dependence·L A Pohorecky, B Newman
Jun 12, 1978·Annals of the New York Academy of Sciences·C T GiambalvoN J Uretsky
Dec 1, 1978·The Journal of Pharmacy and Pharmacology·P N ElliottC D Marsden
Oct 1, 1978·The Journal of Pharmacy and Pharmacology·J A Garcia-SevillaA Carlsson

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