PMID: 7011964Mar 1, 1981Paper

Oxprenolol vs propranolol: a randomized, double-blind, multiclinic trial in hypertensive patients taking hydrochlorothiazide. Veterans Administration Cooperative Study Group

Hypertension

Abstract

Oxprenolol (O) or propranolol (P) was randomly added double-blind to the regimen of 260 patients with mild and moderate hypertension who had not responded to hydrochlorothiazide (H) alone. Both beta-adrenergic blocking agents were titrated over a range of 120 to 360 mg per day while H was continued. After 6 months of treatment, reduction of diastolic blood pressure (DBP) to below 90 mm Hg and at least 5 mm Hg less than the initial DBP was achieved in 50% of patients receiving P+H and 27% of patients taking O+H (p less than 0.001). P+H lowered BP an additional 10.5/9.8 mm Hg compared with 6.8/7.0 mm Hg for O+H (p less than 0.02). Reduction in heart rate was less after O+H (average, 8.4/min) than after P+H (average, 12.3/min, p less than 0.01). The number of dropouts, morbid events, and reported side effects between the two regimens was not significantly different except that more patients complained of impotence with P+H than with O+H (p less than 0.05).

References

Jan 1, 1979·Journal of Clinical Pharmacology·I GavrasH R Brunner
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Citations

Oct 5, 1984·The American Journal of Medicine·N K Hollenberg
Dec 6, 1985·The American Journal of Cardiology·N K Hollenberg
Dec 14, 1987·The American Journal of Cardiology·N K Hollenberg
Nov 10, 1983·The American Journal of Cardiology·S H Taylor
Dec 15, 1986·The American Journal of Medicine·N K Hollenberg
Jan 23, 1987·The American Journal of Cardiology·N K Hollenberg
Feb 11, 1999·The Annals of Pharmacotherapy·D F Thompson, D R Pierce
Apr 2, 1983·British Medical Journal·A Breckenridge
Nov 1, 2001·The Cochrane Database of Systematic Reviews·M CheineK Wahlbeck

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