PMID: 11294516Apr 11, 2001Paper

Oxybutynin does not affect cyclosporin blood levels

Therapeutic Drug Monitoring
J E Springate

Abstract

Cyclosporin is an important immunosuppressive medication used to prevent organ rejection. Drug interactions that alter its blood levels can cause serious problems with toxicity or transplant rejection. Current evidence indicates that both cyclosporin and oxybutynin, which is used to treat bladder dysfunction, are metabolized by the cytochrome P450 3A enzyme system, raising the possibility of an adverse interaction between these medications. However, a study of two children receiving cyclosporin with and without oxybutynin revealed no significant changes in trough blood cyclosporin concentrations.

References

Nov 1, 1995·Clinical Therapeutics·R Seifeldin

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Citations

Nov 11, 2003·Clinical Pharmacokinetics·David R P Guay

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