Oxycodone pharmacokinetics and fetal exposure after intravenous or epidural administration to the ewe

Acta Obstetricia Et Gynecologica Scandinavica
Mari KinnunenMerja Kokki

Abstract

There are limited data on oxycodone pharmacokinetics during pregnancy and on fetal exposure after maternal administration. The present study describes the pharmacokinetics of intravenous (i.v.) oxycodone in pregnant sheep and fetal exposure after intravenous and epidural administration. Ten pregnant sheep received 0.1 mg·kg-1 oxycodone intravenously, and blood samples were collected up to 24 hours. Seven days later, the ewes were randomized to receive 0.5 mg·kg-1 oxycodone intravenously (n = 5) or epidurally (n = 5) as a single bolus, before laparotomy for placement of catheters into the fetal superior vena cava and carotid artery. Paired maternal and fetal blood samples were taken when the fetal arterial catheter was in place and at the end of surgery. Maternal blood samples were taken up to 24 hours. After 0.1 mg·kg-1 oxycodone intravenously, the median clearance was 5.2 L·h-1 ·kg-1 (range 4.6-6.2), but the volume of distribution varied between 1.5 and 4.7 L·kg-1 . The area under the curve was 17 h·ng·mL-1 (range 14-19) and the plasma concentration at 2 minutes 60 ng·mL-1 (range 50-74). Following administration of 0.5 mg·kg-1 intravenously or epidurally, oxycodone concentrations were similar in the maternal and the fetal plas...Continue Reading

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Citations

Jan 18, 2020·Acta Anaesthesiologica Scandinavica·Mari KinnunenMerja Kokki
Jan 18, 2019·Clinical Pharmacokinetics·Mari KinnunenMerja Kokki
Feb 24, 2021·Pharmacology Research & Perspectives·Henriikka HakomäkiMerja Kokki
Jul 18, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Henriikka HakomäkiMerja Kokki

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