Oxygen affinity and equilibrium curve shape in blood of chicken embryos

Respiration Physiology
G N Lapennas, R B Reeves

Abstract

Oxygen equilibrium curves of blood from 4- to 18-day chicken embryos were investigated at 38 degrees C. Curves were recorded at the PCO2 measured in the air cell of each egg. Since arterial PCO2 is known to closely approximate that of the air cell, these curves reflect in vivo arterial pH. Curves were also recorded at a second, higher PCO2, allowing calculation of the curve at estimated venous PCO2 and of physiological curves by interpolation. Half saturation PO2 of physiological curves increased from 38 Torr at 4 days to 52 Torr at 8 days, and then decreased to 31 Torr at 18 days. Increasing blood oxygen affinity late in development favors oxygen loading at the falling PO2 that exists at the chorioallantoic surface, while higher affinity before 8 days may be related to diffusion resistance of the inner shell membrane early in incubation. In blood from 4- to 6-day embryos, the Hill coefficient, nH, of curves at air cell PCO2 increased from 1.5 at oxygen saturation 0.1 to 6.5 at saturation 0.85. After 6 days, nH steadily increased at low saturation and decreased at high saturation. By 18 days, nH varied only from 2 to 3.4. A biphasic equilibrium curve shape (hump at the low end of the oxygen equilibrium curve) developed in 4- an...Continue Reading

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Citations

Apr 1, 1983·Respiration Physiology·G N Lapennas, R B Reeves
Mar 1, 1988·Respiration Physiology·H J Meuer, R Baumann
Apr 19, 2008·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Kristen HentyThomas Brittain
Nov 12, 2005·European Journal of Clinical Investigation·R Baumann, S Dragon
Feb 22, 2011·Proteins·Mitra S Rana, Austen F Riggs
Aug 4, 2004·Respiratory Physiology & Neurobiology·F León-Velarde, C Monge-C
Oct 7, 2008·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Jonas R RasmussenThomas Brittain
Feb 26, 1999·The Journal of Biological Chemistry·J E KnappM L Hackert
Nov 26, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Rosemarie BaumannStefanie Dragon
Mar 20, 2003·News in Physiological Sciences : an International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society·Stefanie Dragon, Rosemarie Baumann

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