PMID: 1130194Mar 1, 1975

Oxygen affinity of haemoglobin and red cell 2,3-diphosphoglycerate in childhood diabetes

Acta paediatrica Scandinavica
J DitzelN D Peters


Red cell 2,3-diphosphoglycerate (2,3-DPG) and the oxygen haemoglobin dissociation curve (ODC) were determined in 32 ambulatory, non-acidotic diabetic children and in 49 healthy children. Despite the fact that the diabetic children had, on average, an increased haemoglobin concentration, their erythrocytes contained significantly more 2,3-DPG than normal. Both in diabetic and in healthy children a negative relationship was found between the content of 2,3-DPG and the haemoglobin concentrations. No relationship was present between the plasma glucose and the 2,3-DPG concentration. The concentration of plasma inorganic phosphate (Pi) in the diabetic children was significantly higher than in the control children, and for all children there was a significant relationship between the 2,3-DPG and the Pi. In the diabetics 2,3-DPG was positively correlated to the P50 (7.40) and to the P50 (in vivo ph) of the ODC. However, despite the significant increase in 2,3-DPG among the diabetic children the average P50 (7.40) and P50 (in vivo pH) was not increased as compared with the control children. The inhibitory factor preventing the oxygen affinity from decreasing among the diabetics was strongly correlated to an increase in the mean corpuscu...Continue Reading


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Related Concepts

Phosphate Measurement
Oxygen Affinity
Diphosphoglyceric Acids
Hemoglobin Measurement
Specimen Type - Erythrocytes
Red Blood Cell Count Measurement
Specialty Type - Ambulatory
Diabetes, Autoimmune

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