PMID: 6108999Sep 1, 1980Paper

Oxygen affinity of tyrosine and tryptophan hydroxylases in synaptosomes

Journal of Neurochemistry
I R Katz

Abstract

Tyrosine and tryptophan hydroxylase activities were studied in a synaptosome-enriched (P2) preparation from the rat striatum. Care was taken to avoid the potential diffusional artifacts to which measures of oxygenase activities in respiring tissue are, in general, subject. Tyrosine hydroxylase exhibited a Km for oxygen of 2 to 3 mm Hg under a variety of conditions. Tryptophan hydroxylase exhibited a Km of 3 to 4 mm Hg at C.S.F. levels of tryptophan (10 microM). The Km increased to 8 to 10 mm Hg at 2 microM tryptophan. These values are all consistent with some degree of unsaturation with respect to oxygen in vivo.

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Citations

Jan 1, 1996·European Journal of Applied Physiology and Occupational Physiology·H K StrüderK Weber
May 24, 2007·Amino Acids·M RostrupJ Haavik
Jan 1, 1993·Progress in Biophysics and Molecular Biology·M C Boadle-Biber
Apr 2, 1987·Biochimica Et Biophysica Acta·S H FeinsilverD M Raybin
Jan 1, 1986·Neurochemistry International·G Curzon
Jan 1, 1990·Neurochemistry International·G SchulzeC Fähndrich
Aug 1, 1982·Psychosomatics·I R Katz
May 13, 1998·Acta Physiologica Scandinavica·M Rostrup
Apr 7, 1999·Acta Physiologica Scandinavica·H K StrüderK Weber
Mar 1, 1984·Journal of Neurochemistry·R G Knowles, C I Pogson
Mar 9, 2018·Harvard Review of Psychiatry·Brent M KiousPerry F Renshaw
May 16, 2019·International Review of Psychiatry·Brent M KiousSrijan Sen
Jan 1, 1986·Neurochemistry International·D M KuhnM B Youdim
Sep 15, 2021·International Journal of Geriatric Psychiatry·Mia F Valenzuela-IglesiasJosé F Parodi

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