PMID: 6171249Jan 1, 1981Paper

Oxygen-binding and immunological properties of complexes between dextran and animal haemoglobins

The Biochemical Journal
P G CunningtonJ T Wong

Abstract

Complexes of dextran 20 000 with haemoglobins of sheep, rabbit, dog, bovine and human origin were prepared through alkylation of haemoglobin by N-bromoacetylaminoethylamino-dextran. The yields were uniformly high. Complex-formation in each case was accompanied by the disappearance of reactive thiol groups on the haemoglobin, and by an increase in the affinity of the haemoglobin for oxygen. The immunological properties of dog, rabbit and sheep dextran-haemoglobin were investigated in both homologous and heterologous species. The complexes were found to be non-immunogenic in the homologous species. In heterologous species the anti-haemoglobin response induced by each complex was generally of a similar level to that induced by the haemoglobin alone.

Citations

Jan 1, 1988·Biomaterials, Artificial Cells, and Artificial Organs·J T Wong
Jan 1, 1992·Biomaterials, Artificial Cells, and Immobilization Biotechnology : Official Journal of the International Society for Artificial Cells and Immobilization Biotechnology·B A TeicherK Menon
Jan 1, 1992·Biomaterials, Artificial Cells, and Immobilization Biotechnology : Official Journal of the International Society for Artificial Cells and Immobilization Biotechnology·T N EstepF Aono
Jan 1, 1993·Journal of Cancer Research and Clinical Oncology·B A TeicherK Menon
Feb 1, 1996·Anesthesia and Analgesia·N M DietzM A Warner
May 30, 2015·Artificial Cells, Nanomedicine, and Biotechnology·Timothy N Estep
Jan 9, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Jun ZhangLian Zhao
Oct 9, 1991·Biochemical Pharmacology·W H KoS C Tam
Aug 1, 1986·International Journal of Radiation Oncology, Biology, Physics·J T Wong, R P Hill
Sep 1, 1991·International Journal of Radiation Oncology, Biology, Physics·B A TeicherK Menon

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