Oxygen changes drive non-uniform scaling in Drosophila melanogaster embryogenesis

BioRxiv : the Preprint Server for Biology
Steven G Kuntz, Michael B Eisen


In Drosophila embryogenesis, increasing either oxygen concentration or temperature accelerates development. Having previously investigated temperature’s impact on embryogenesis, we characterized developmental response to oxygen levels using time-lapse imaging. Changing oxygen concentrations greatly impact survival, with developmental rate changes that are dwarfed by those induced by temperature. While extreme temperatures increase early embryo mortality, mild hypoxia increases arrest and death during mid-embryogenesis and mild hyperoxia increases survival over normoxia. Though not independent, the reactions to temperature and oxygen are fundamentally different, with developmental time being inversely proportional to oxygen concentration but logarithmically related to temperature. Most notably, while development scales uniformly with temperature, oxygen changes drive developmental heterochrony. Morphological processes change with oxygen concentration at different rates. Gut formation is more severely slowed by decreases in oxygen, while head involution and syncytial development are less impacted than the rest of development. These data reveal that uniform scaling, seen with changes in temperature, is not the default result of ad...Continue Reading

Related Concepts

Entire Embryo
Impacted Tooth
Cessation of Life
Time-Lapse Imaging
Embryonic Development
Response to Oxygen Levels

Related Feeds

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.