Oxygen dependency of mitochondrial metabolism indicates outcome of newborn brain injury

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Gemma BaleIlias Tachtsidis

Abstract

There is a need for a method of real-time assessment of brain metabolism during neonatal hypoxic-ischaemic encephalopathy (HIE). We have used broadband near-infrared spectroscopy (NIRS) to monitor cerebral oxygenation and metabolic changes in 50 neonates with HIE undergoing therapeutic hypothermia treatment. In 24 neonates, 54 episodes of spontaneous decreases in peripheral oxygen saturation (desaturations) were recorded between 6 and 81 h after birth. We observed differences in the cerebral metabolic responses to these episodes that were related to the predicted outcome of the injury, as determined by subsequent magnetic resonance spectroscopy derived lactate/N-acetyl-aspartate. We demonstrated that a strong relationship between cerebral metabolism (broadband NIRS-measured cytochrome-c-oxidase (CCO)) and cerebral oxygenation was associated with unfavourable outcome; this is likely to be due to a lower cerebral metabolic rate and mitochondrial dysfunction in severe encephalopathy. Specifically, a decrease in the brain tissue oxidation state of CCO greater than 0.06 µM per 1 µM brain haemoglobin oxygenation drop was able to predict the outcome with 64% sensitivity and 79% specificity (receiver operating characteristic area under...Continue Reading

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Citations

Jul 4, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Miled BourourouNicolas Blondeau
Sep 6, 2020·Physiological Reports·Gemma BaleIlias Tachtsidis
Apr 17, 2020·Antioxidants & Redox Signaling·Marianela RodríguezRafael Radi
Jan 20, 2021·Journal of Perinatology : Official Journal of the California Perinatal Association·Eniko SzakmarMohamed El-Dib
Apr 27, 2021·Frontiers in Pediatrics·Kelly Harvey-JonesSubhabrata Mitra
Nov 7, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Ji-Hyun ParkKazuhide Hayakawa

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