Oxygen derived variables in acute respiratory failure

Critical Care Medicine
H D CovelliW K Tuttle

Abstract

The clinical course of 33 patients with acute respiratory distress syndrome (ARDS) was monitored by noninvasive oxygen derived variables and compared to data obtained by invasive monitoring. A total of 350 data points were used to compare the physiologic shunt fraction (Qsp/Qt) with the ratio of arterial oxygen to inspired oxygen concentration (PaO2/FIO2), the alveolar-arterial oxygen pressure difference [P(A-a)O2], the respiratory index (RI)-[P(A-a)O2/PaO2], and the ratio of arterial oxygen to alveolar oxygen (a/A). The PaO2/FIO2 ratio, the RI and the aA ratio correlated well with Qsp/Qt (r = 0.87 to 0.94). The P(A-a)O2 correlated less well (r = 0.68). Changes in the cardiac index (CI) and the arteriovenous oxygen content difference C(a-v)O2 had only a minimal effect on the correlation of the oxygen derived variables with Qsp/Qt, although a higher correlation resulted when these extrapulmonary factors were within normal range. We conclude that a number of oxygen derived variables may accurately reflect the degree of Qsp/Qt. The PaO2/FIO2 ratio is the easiest of these variables to calculate, yet accurately predicts the degree of Qsp/Qt throughout a course of acute respiratory failure.

Associated Clinical Trials

Citations

Jan 1, 1990·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·I A HerrickA B Froese
Feb 1, 1991·Computer Methods and Programs in Biomedicine·R RudowskiG Matell
Jul 31, 1999·Archives of Medical Research·I Maulen-RadovanM Márquez Aguirre
Feb 11, 2005·The New England Journal of Medicine·Nir Hoftman
Jan 1, 1997·Critical Care Medicine·M S Gowda, R A Klocke
Mar 21, 1998·Transplantation·J F WhitingD W Hanto
Jun 10, 2003·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Luigi GagliardiFabio Mosca
Dec 4, 2008·Critical Care Medicine·Jérôme Allardet-ServentLaurent Papazian
Jan 1, 1995·Acta Anaesthesiologica Scandinavica. Supplementum·J H Wandrup
Dec 1, 1988·The American Review of Respiratory Disease·M J Tobin
Mar 1, 1989·The American Review of Respiratory Disease·R HällgrenJ Modig
May 13, 2006·American Journal of Respiratory and Critical Care Medicine·João B BorgesMarcelo B P Amato
Jan 10, 2014·Journal of Clinical Monitoring and Computing·Geoffrey G LockwoodJ Gareth Jones
Jan 11, 1992·World Journal of Surgery·W R Clark
Feb 1, 1989·Scandinavian Journal of Clinical and Laboratory Investigation·L BaggeJ Modig
Jan 16, 2013·Critical Care Medicine·Andreas W ReskeMarcelo B P Amato
Jan 1, 1988·Intensive Care Medicine·J RäsänenW L Garner
Oct 1, 1988·Acta Anaesthesiologica Scandinavica·H Zetterström
Oct 17, 2002·The Veterinary Clinics of North America. Small Animal Practice·Lisa L Powell
Jul 5, 2013·The Journal of Trauma and Acute Care Surgery·John F BilelloKrista L Kaups
Sep 13, 2016·Critical Care Medicine·John R Feiner, Richard B Weiskopf
Apr 30, 2017·Expert Review of Respiratory Medicine·Pongdhep TheerawitPaolo Pelosi
Nov 1, 1995·The Journal of Trauma·F B RogersD B Hoyt
May 23, 2020·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·André Y DenaultPaul Ouellet
Sep 17, 2020·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Jorge CastelaoJosé Luis Izquierdo
Aug 1, 1997·International Journal of Clinical Monitoring and Computing·B C Fong, D J Doyle

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.