PMID: 6792651Jan 1, 1981

Oxygen-effect as an inhibition of repair: radiation studies on excision repair deficient mei-9L1-embryos of Drosophila

Radiation and Environmental Biophysics
H Fritz-NiggliP Schweizer

Abstract

The excision repair deficient mei-9L1-embryos of Drosophila melanogaster are up to four times more radiosensitive than normal +/+ embryos. The lack of oxygen-effect in the repair deficient 4-h-embryos and the reduced O2-effect in the 13/4-h embryos suggest an interpretation of the oxygen effect as a modification of the ability to repair. The conversion of the early death (heavy damage) to late death (slight damage) by irradiation of normal embryos in N2 supports this interpretation. This theory can also explain the dependence of O2-effect on LET. The spontaneous lethality and the increase in radiosensitivity depend in heterozygous mei-9L1-embryos strictly upon the genotype of the mother, thus representing a maternal effect.

References

Jul 1, 1979·International Journal of Radiation Oncology, Biology, Physics·M Quintiliani
Jan 1, 1979·Radiation and Environmental Biophysics·H H Rossi
Oct 2, 1975·Radiation and Environmental Biophysics·R Wideröe
Sep 1, 1974·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·T ALPER, P E Bryant
Jan 21, 1970·Biochimica Et Biophysica Acta·U HagenH Kröger
Jan 1, 1980·Journal of Cancer Research and Clinical Oncology·H YokoyamaT Niijima
Dec 1, 1980·The British Journal of Radiology·S Hornsey
Nov 3, 1956·Nature·T ALPER, P HOWARD-FLANDERS

Citations

Jan 15, 1989·Experientia·T ALPER, W A Cramp

Related Concepts

Metazoa
Dose-Response Relationship, Radiation
Drosophila melanogaster
Energy Transfer
Decline, Mortality
Dioxygen
Radiation Tolerance

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